Biopharma

Abstract Host cell proteins (HCPs) are process-related impurities in a therapeutic protein expressed using cell culture technology. This review presents...

Abstract Ionizable aminolipids enable lipid nanoparticles (LNPs) to encapsulate nucleic acids at neutral pH and to release their cargo upon...

Abstract Since the first market authorization of RNA therapies, just eight years ago, the field has witnessed an extraordinary expansion,...

Abstract Permeation enhancers (PE) such as hyaluronidase are increasingly incorporated into subcutaneous (SC) biologic drug formulations to improve drug absorption....

Abstract Powder flow is a constant concern in the production of solid dosage forms. Its concise and reliable determination and...

Abstract KRAS G12S mutations in non-small cell lung cancer (NSCLC) remain refractory to current targeted therapies, with few clinical options and...

Highlights PLGA/PBAE coordinates endosomal escape and timely mRNA release in APCs PLGA/PBAE enhances mRNA transfection in APCs and promotes immune...

Abstract Background: An efficient formulation of lipid nanoparticles (LNPs) is often considered crucial in the successful development of nucleic acid...

Abstract Polymeric micelles are promising nanocarriers for improving the solubility and therapeutic efficacy of poorly water-soluble drugs. In this study,...

Abstract Pediatric drug delivery presents unique challenges due to physiological and pharmacological differences across age groups, requiring specialized formulation approaches...