In Vitro and In Vivo Studies of a Verapamil-Containing Gastroretentive Solid Foam Capsule

2. February 2022

Gastroretentive systems may overcome problems associated with incomplete drug absorption by localized release of the API in the stomach. Low-density...

Current trends in drug delivery and excipients in the pharmaceutical industry

31. January 2022

An outlook on the importance of excipients by pharmaexcipients which will also be part of the upcoming ExciPerience Event -...

Sampling and diversion strategy for twin-screw granulation lines using batch statistical process monitoring

26. January 2022

Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects...

graphical abstract of The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous Fluid Bed Dryer after Twin Screw Wet Granulation

The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous Fluid Bed Dryer after Twin Screw Wet Granulation

17. January 2022

Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in...

In-depth analysis of the long-term processability of materials during continuous feeding

17. January 2022

This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative...

Fig. 2. Unit operations in the direct compaction line including (a) loss-in-weight feeders and the continuous blender, (b) the tablet press with the ECVT powder mass flow measurement at the inlet and weigh scale-based tablet production rate measurement at the outlet, and (c) the hopper associated with the tablet press with a camera and image analysis-based level measurement system.

Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct Compaction Tablet Manufacturing Process

16. January 2022

While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet...

The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process

13. January 2022

The effect of two screw configurations with varying stagger angle was evaluated on the liquid amount required to produce good...

Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

5. January 2022

The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With...

Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements

3. December 2021

The influence of different tableting process parameters on lead-lag was studied by collecting in-line near-infrared (NIR) spectra in the filling...

Using Residence time distribution in pharmaceutical solid dose manufacturing – a critical review

10. November 2021

While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality...

Continuous manufacturing