Cyclodextrin

Abstract The oral bioavailability and therapeutic efficacy of a compound are largely determined by its aqueous solubility and interfacial partitioning....

Abstract Purpose This study aims to evaluate the ability of various cyclodextrins (CDs) to enhance the aqueous solubility of haloperidol...

Oral drug delivery to the colon remains a formidable challenge due to the harsh conditions of the upper gastrointestinal tract,...

Abstract Similar to other routes of administration, pulmonary formulations typically contain excipients. The panel of substances that can be used...

Abstract Hot melt extrusion (HME) is a widely used method of taste masking in medication formulations, notably for bitter Active...

Abstract Improving nasal spray use experience is typically not addressed as a key product requirement even though sensations of bitterness,...

Abstract The work involved taste masking of primaquine phosphate (PMQ), an intensely bitter drug used in the prevention and treatment...

Abstract Purpose Azelaic acid (AZE) is a widely used agent in acne treatment, but its poor water solubility limits its...

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by...

Abstract The present study deals with development and characterization of quercetin (QCT) – loaded sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion complex (IC) incorporated...