Cyclodextrin

Cyclodextrins (CD) and derivatives are functional excipients that can improve the bioavailability of numerous drugs. Because of their drug solubility improving properties they are used in many pharmaceutical products. Furthermore, the stability of small molecular drugs can be improved by the…
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We invite you to our next webinar: "Rational Selection of Cyclodextrins for the Solubilization of Poorly Soluble Oral Drugs" Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Formulation in a complex with…
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Abstract The incorporation of phloretin (PHL), a dihydrochalcone flavonoid, in functional foods is usually hampered by its low aqueous solubility. In this regard, we investigated the impact of complexation of PHL with sulfobutylether-β-cyclodextrin (SBE-β-CD, Captisol®) to overcome its limitation.…
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Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects. Nanotechnology-based formulations for vaginal administration…
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Introduction Carbamazepin (CBZ), a widespread used antiepileptic drug, branded as Tegretol, firstly was launched in form of Active Pharmaceutical Ingredient (API) as a commercially available polymorphic form III. Additionally, crystallographic studies on crystal packing motifs of carbamazepine…
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ABSTRACT The field of pharmaceutical formulation is constantly evolving, driven by the need for improved drug delivery systems and enhanced therapeutic outcomes. One critical aspect of this evolution is the development and utilization of novel excipients. This review explores the types and examples…
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Abstract Silymarin (SIL) is a poorly water-soluble flavonoid reported for different pharmacological properties. Its therapeutic applications are limited due to poor water solubility. In this study, the solubility of silymarin has been enhanced by preparing freeze-dried binary and ternary complexes…
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Etoricoxib, as a model drug, has a poor solubility and dissolution rate. Cyclodextrin derivatives can be used to solve such a problem. A comparative study was run on three cyclodextrin derivatives, namely β-CD, HP β-CD, and SBE β-CD, to solve the drug problem through the formulation of solid…
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Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of…
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Abstract Purpose Glimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type, is characterized by its low solubility and high permeability. In order to increase glimepiride’s aqueous solubility and hence increase its…
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