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Oral Solid Dose – Direct Comparison of Pharmacel® 101 and Pharmacel® 102
Pharmacel 101 and 102
High-quality excipients
Oral Solid Dose
A comprehensive range of highly consistent excipients for OSD formulations, including a full range of lactose (milled monohydrate, sieved monohydrate, micronized, anhydrous, spray dried, and granulated), cellulosics and starches portfolio comprising of microcrystalline cellulose (MCC), croscarmellose sodium, sodium starch glycolate, starches and multifunctional, co-processed excipients.
DFE’s product portfolio in this range includes, among others, the two popular products Pharmacel® 101 and Pharmacel® 102. Find out more about these two products in a direct comparison here:
Pharmacel® 101
Pharmacel® 101 Microcrystalline cellulose (MCC) has been developed specifically as a key component for wet granulation and dry granulation formulations. DFE Pharma offers Pharmacel® 101 from two high quality production sites.
Pharmacel® 102
Microcrystalline cellulose (MCC) compacts more effectively than any other excipient making Pharmacel® 102 the ideal choice for direct compression and dry granulation formulations. It’s versatility in direct compression extends to very high dose actives, where compactability is at a premium.
Benefits
Consistency
Pharmacel® is industry leading with high batch-to-batch consistency on functional properties allowing you low risk during production and in your formulation development.
Pharmacel® 101
Pharmacel® 102
Pharmacel® and lactose formulations
DFE Pharma is the only global excipient manufacturer offering it’s customers both lactose and microcrystalline cellulose products for development of pharmaceutical formulations. Combination of Pharmacel® with one of the lactose grades offered by DFE Pharma provides additional benefit to formulations, by achieving the perfect combination of brittle and plastic excipient behavior.
Pharmacel® 101
Wet granulation
Pharmacel® 101 microcrystalline cellulose (MCC) has
been developed specifically as a key component for
wet granulation formulations. Using Pharmacel® 101
ensures even distribution of the granulating fluid,
which in turn means uniform granulation and drying
processes. Wet granulation with Pharmacel® 101 is a
reliable, easily repeatable and robust process. Tablets
made using Pharmacel® 101 show excellent
compaction and disintegration properties.
Dry granulation
Pharmacel® 101 microcrystalline cellulose (MCC)
is also an ideal excipient for use in dry granulated
formulations. Ribbons do not stick to the compaction
rolls during roller compaction and dry granulation
can be used in formulations with a high drug dosage.
For dry granulation Pharmacel® 101 opens up vital
production synergies. Used with a brittle excipient,
such as SuperTab® 21AN anhydrous lactose, the
result is an ideal combination of high tablet strength
and insensitivity to re-compaction, leading to
outstandingly robust dry granulation formulations.
Pharmacel® 102
Physical – chemical properties
Pharmacel® 102 has good flow properties enabling
high speed direct compression tableting. In addition,
tablets of high tensile strength with low ejection
forces can be obtained with low compaction forces.
Pharmacel® 102 has some lubrication properties
facilitating smooth tableting experience.
Facts
Typical product data
Complies with Ph.Eur., USP-NF, JP, IP
Kosher & Halal certified
Particle size distribution
Method: dry laser diffraction
Pharmacel® 101
Pharmacel® 102
High protective packaging
See the full product brochures on “Pharmacel® 101” and “Pharmacel® 102” here
(click the pictures to download the brochures)
Pharmacel® 101
Pharmacel® 102
Source: DFE Pharma, brochures “Pharmacel® 101” and “Pharmacel® 102”
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