Drug Delivery

Abstract Current protein-based therapies often rely on intravenous and subcutaneous injections leading to patient discomfort due to the need for frequent administration. Oral administration route presents a more patient-friendly alternative, but overcoming the challenge of low drug…
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Abstract This study investigated sublingual drug permeation and administration using five model drugs with diverse physicochemical properties, employing New Zealand White Rabbit sublingual mucosa for in vitro experiments and New Zealand White Rabbits for in vivo studies. The research aimed to…
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Abstract Drug delivery systems efficiently and safely administer therapeutic agents to specific body sites. Liposomes, spherical vesicles made of phospholipid bilayers, have become a powerful tool in this field, especially with the rise of microfluidic manufacturing during the COVID-19 pandemic.…
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Abstract Curcumin, a bioactive compound derived from turmeric, possesses numerous pharmaceutical properties; however, its poor aqueous solubility and permeability result in low bioavailability. This study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) using different…
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Fast dissolving drug delivery systems offers a solution for pediatric, geriatric, mentally ill people and those patients having difficulty in swallowing tablets or capsules. In the present study, an attempt had been made to prepare fast dissolving tablets of Bisoprolol Fumarate, an antihypertensive…
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From optimized gastric resistance to enhanced bioavailability - EUDRACAP® leverages the functional versatility and safety of EUDRAGIT® to solve key challenges in oral drug delivery. Pharmaceutical companies launching new oral drugs need the right coated capsule formulation to enhance performance…
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Docetaxel (DTX) has become widely accepted as a first-line treatment for metastatic breast cancer; however, the frequent development of resistance provides challenges in treating the disease.C60 fullerene introduces a unique molecular form of carbon, exhibiting attractive chemical and physical…
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Abstract Purpose of review Herein, we present an overview of innovative oral technologies utilized in colonic drug delivery systems that have made significant translational and clinical advancements to treat inflammatory bowel disease (IBD) in recent years. Recent findings The colon is home to…
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Abstract This study aims to develop chitosan-based apigenin (AGN) spray-dried solid dispersions (SDSDs) within a 3D pill. AGN SDSDs were prepared using 1:1 (AC1), 1:1.5 (AC2), and 1:2 (AC1) apigenin/chitosan weight ratios. The results of the process yield were found to be (87.5%, 94.2%, and…
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Abstract Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST was formulated. Methods: I-optimal mixture design was used for optimization of DST-loaded SNEDDS using…
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