Pharma Excipients
Excipient for Inhalation
Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting…
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options. COVID-19 needs daunting routes such as nano-antivirals. Hence, the role of nanotechnology is very critical in combating this nano-enemy…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Emerging trends in inhaled drug delivery
Ideally, inhaled therapy is driven by the needs of specific disease management. Lung biology interfaces with inhaler performance to allow optimal delivery of therapeutic agent for disease treatment. Inhalation aerosol products consist of the therapeutic agent, formulation, and device. The…
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Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations
We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can increase drug loading up to 95% while maintaining good aerosol performance. Drug loading affected the specific surface area and…
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New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase…
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Respiratory Drug or Vaccine Delivery Using Nanoparticles
Respiratory diseases account for a very significant portion of worldwide morbidity and mortality but to-date only a limited number of therapeutics are available for direct delivery via inhalation. Nanotechnology offers a range of potential benefits to facilitate the targeted delivery/co-delivery of…
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Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and…
Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity. Indeed, it is estimated that only 10–15% of the drug reaches the deep lung while 20% of…
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Spray-dried liposomes: A study of the effect of carbohydrate carrier and concentrations on liposome…
Background and objective: Dry powder inhalation provide many promising features for
drug delivery to the pulmonary system, such as localization of drug within the lungs, drug
retention in the respiratory tract, and reduced systemic toxicities. This study aimed to
prepare dry powders of liposomes…
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Kerry Launches Aero Flo Brand Inhalation Grades of Lactose at DDL 2019
Building on a long and well established history of supplying world class pharmaceutical grade lactose, film coatings, and tableting systems, Kerry introduces Aero Flo® Inhalation lactose, designed to meet the growing demand for lactose that is suitable for developing dry powder inhalers.
Aero…
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Amino acids as stabilizers for spray-dried simvastatin powder for inhalation
Background
The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation.
Objectives
The aim of this study was to investigate the stabilizing effect of different amino acids on spray-dried…
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