Anhydrous Lactose Family by Kerry
Excipients for direct tabletting and granulation
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk. Depending on the temperatures used to crystallize and dry the lactose solution, it may be produced in either of two crystalline types: monohydrate or anhydrous.
In addition, the lactose disaccharide also has the ability to form two stable isomers known as alpha-lactose and beta-lactose. These two isomers differ in the orientation of the hydroxyl group in the glucose moiety. The monohydrate crystal in primarily the alpha-form, whereas the anhydrous crystal is primarily the beta-form (Zadow, 1984). At equilibrium in water at room temperature, both forms will be present as 62.3% beta-form and 37.7% alpha-form (Whittier, 1944).
- Eliminate or reduce higher cost or multiple excipients
- Replace wet granulation technology, reduce equipment and process validation
- Excellent tablet hardness at low compression forces
- High purity and no yellowing – pigment free
- Optimal for tableting with unstable active ingredients
- Moisture stable – 4 year shelf life
- Physically and chemically stable
- Low friability & excellent dissolution
- Consistent re-worked tablet properties
- Several grades and custom capabilities
- Certified Kosher and Animal Rennet-Free
- Over 75 years experience – batch to batch consistency
Products & Recommended Applications
See the products in our shop:
General Physical and Chemical Characteristics
Anhydrous Lactose by Kerry is a disaccharide obtained from the whey fraction of milk, and consists of one glucose and one galactose moiety.
Sheffield™ Anhydrous Lactose is a crystalline mixture of beta and alpha anomers and meets all requirements of the National Formulary.
Other Physical Characteristics
Free-flowing, non-hygroscopic powder. White to creamy white in color, free of sediment and with excellent stability. A 10% solution (in boiling water) is clear to nearly colorless. Soluble in water at 25°C (77°F) is 40g/100ml.
Packaging and Storage
Store in cool, dry area with container closed when not in use. A minimum shelf life of 48 months is expected for unopened packages.
The standard packaging is in 80kg polyethylene lined fiber drums with tamper evident seals. All products are also available in 100lb drums and 25kg paper sacks upon request.
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Particle Size Curves
See the full brochure on “Anhydrous Lactose Family by Kerry“ here
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Source: Kerry brochure “Anhydrous Lactose Family by Kerry”
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