Prediction of tablet weight variability from bulk flow properties by sparse modeling

5. July 2022

Die filling is a critical step in the pharmaceutical tableting process as it determines the uniformity in tablet weight, which...

Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability

4. July 2022

Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges...

A multivariate formulation and process development platform for direct compression

1. July 2022

The efficient development of robust tableting processes is challenging due to the lack of mechanistic understanding on the impact of...

On the complexity of predicting tablet capping

30. June 2022

Predicting tablet defects, such as capping, that might occur during manufacturing, is a challenge in the pharmaceutical industry. In the...

A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation

29. June 2022

Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the...

graphical abstract of System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

25. February 2022

Mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be...

figure 7 of A Hybrid Model to Predict Formulation Dependent Granule Growth in a Bi-Component Wet Granulation Process

Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

28. October 2021

The solution behavior and membrane transport of multidrug formulations were herein investigated in a biorelevant medium simulating fasted conditions. Amorphous...

formulation