Freeze Drying

Abstract Hypothesis During spray freeze drying (SFD), vitrification, recrystallization, and polymorphic transitions govern particle morphology and mechanical integrity. We hypothesize...

Abstract Extracellular vesicles (EVs) hold great promise as a novel therapeutic modality. While their use as certain formulations has been...

Spin freeze-drying (SFD) has emerged as a potential breakthrough in pharmaceutical lyophilization. It promises over 90 % reductions in cycle time...

Abstract Background: Despite the growing importance of polypeptide-based drugs in clinical therapy, studies investigating the stability of their freeze-dried formulations...

Abstract Background/Objectives: Dihydroquercetin (DHQ), also known as taxifolin, is a natural flavonoid which has anti-inflammatory and wound-healing biological effects. One...

Abstract Introduction: Formulation research benefits from high-throughput excipient screening methods, considering the ever-growing excipient space. We investigate the use of 384-well...

Freeze-drying Technology in Pharmaceutical and Biomedical Product Development Freeze-drying Technology in Pharmaceutical and Biomedical Product Development See the new book,...

Abstract Solid-state protein formulations are known to exhibit enhanced storage stability compared to their liquid dosage form counterparts. pH is...

A library of 16 lipid nanoparticle (LNP) formulations with orthogonally varying lipid molar ratios was designed and synthesized, using polyadenylic acid ...

Freeze drying is a commonly used method for preserving probiotic bacteria and live biotherapeutic products. Before drying, the bacterial cells...