Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

26. November 2023

Abstract Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such...

Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review

23. November 2023

Abstract Background Process intensification is a major hurdle in pharmaceutical process scale-up. Solvent removal strategies have limited the effectiveness of...

Tailoring Dry Microparticles for Pulmonary Drug Delivery: Ultrasonic Spray Freeze-Drying with Mannitol and Salbutamol Sulphate

12. November 2023

Abstract Spray freeze-drying has emerged as a valid alternative to traditional spray drying to produce therapeutic dry microparticles. In particular,...

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

5. April 2023

Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success,...

Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

21. April 2021

Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting...

Impact of Fast and Conservative Freeze-Drying on Product Quality of Protein-Mannitol-Sucrose-Glycerol Lyophilizates

13. March 2018

13. March 2018 Purpose Mannitol/sucrose formulations are employed to generate lyophilizates for biopharmaceuticals with an elegant cake appearance. The...

Freeze Drying