Gellan Gum is a versatile polysaccharide that has found extensive applications in various industries, including the pharmaceutical sector. Known for its unique rheological properties and gelling abilities, gellan gum has become a popular choice for pharmaceutical formulations, contributing to the stability and performance of various drugs.
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Gellan Gum
Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid…
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the treatment options still represent stability concerns since…
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Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Utilization of natural superdisintegrants in mouth dissolving tablet: A simplified review
Many drugs belong to BCS class-2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability; however, in many cases, immediate onset of action is required than conventional therapy. Tablet is the most popular among all dosage forms…
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Design and development of polymethylmethacrylate-grafted gellan gum (PMMA-g-GG)-based pH-sensitive…
The objective of the present study was to develop a pH-sensitive drug delivery system by using polymethylmethacrylate-grafted gellan gum (PMMA-g-GG). PMMA-g-GG was synthesized by free radical polymerization reaction by using redox initiator ceric ammonium nitrate (CAN), and a series of graft…
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Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The aim of this study was to develop “instant” jellies as…
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A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery
The aim of the present study was the development of a novel gellan gum derivative exhibiting mucoadhesive properties for nasal application.
Accomplishing this, amino groups have been introduced to the polymeric backbone. The resulting synthesis products were characterized in terms of the amount…
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Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of…
Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation. The structure and substitution degrees of these derivatives were confirmed by 1H NMR- and FTIR-spectroscopy. These derivatives are more hydrophobic compared to…
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Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment
14. December 2017
Purpose
Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation,…
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Gellan Gum Fluid Gels for Topical Administration of Diclofenac
30. October 2016
Abstract
Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum…
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