Gellan Gum is a versatile polysaccharide that has found extensive applications in various industries, including the pharmaceutical sector. Known for its unique rheological properties and gelling abilities, gellan gum has become a popular choice for pharmaceutical formulations, contributing to the stability and performance of various drugs.
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Gellan Gum
Fabrication Methods and Form Factors of Gellan Gum-Based Materials for Drug Delivery and Anti-Cancer…
Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main challenges of cancer treatment. Exploration of drug delivery methods is a growing field of research, which involves a variety of materials and processing techniques. A natural polymer, gellan gum…
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Development and in-vitro in-vivo characterization of in-situ gelling sustained-release nevirapine…
Nevirapine is a BCS class-II drug used in the treatment and prevention of HIV/AIDS, specifically HIV-1. This study was aimed to develop and evaluate a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension (SRNPS) for treatment and prevention of mother-to-child…
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Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects
Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product development. The purpose of this study is to determine the potentiality of…
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Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral…
Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g., dysphagia) in the older patient population, especially when…
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Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based…
The objective of this study is to use a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals based intranasal in situ gel (IG) for nose-to -brain delivery of drug. The harmine nanocrystals (HAR-NC) as model drug were prepared by coupling homogenization and spray-drying…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid…
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the treatment options still represent stability concerns since…
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Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Utilization of natural superdisintegrants in mouth dissolving tablet: A simplified review
Many drugs belong to BCS class-2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability; however, in many cases, immediate onset of action is required than conventional therapy. Tablet is the most popular among all dosage forms…
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