Granulation

In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw...

This chapter discusses different excipients traditionally used in granulation applications and the emerging high-functionality co-processed excipients that can improve granulation...

Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the...

Binders or “granulating agents” are a critical formulation component in tablets made by direct compression, as well as dry, wet,...

Characterization of drug substances and excipients is a very important step at the preformulation phase of product development. Although testing...

This study aimed to compare the manufacturability and granule and tablet properties of green fluidized bed granulation (GFBG) and of...

Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and...

Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of...

The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs)...

Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing...