Hot-melt extrusion

Abstract Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of...

Abstract Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble...

Abstract Congenital diaphragmatic hernia (CDH) is a rare disease in which neonates are born with pulmonary hypoplasia and a diaphragmatic...

Abstract Recent developments in pharmacogenetics have emphasised the importance of customised medication, driving interest in technologies like FDM 3D-printing for...

Abstract Background/Objectives: Chagas disease is a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are...

Abstract Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP...

Abstract The hot-melt extrusion process is currently considered a prominent manufacturing technique in the pharmaceutical industry. The present study is...

Abstract Currently, most amorphous solid dispersion (ASD) formulations contain a single polymer to stabilize an amorphous drug. However, a single...

Abstract Kollidon® SR is one of the recent versatile coprocessed excipients in the formulation of modified release dosage forms. It...

Abstract This paper presents a comprehensive investigation of the manufacturing of itraconazole (ITZ) amorphous solid dispersions (ASDs) with Kollidon® VA64...