Hot-melt extrusion

Abstract Background/Objectives: The oral delivery of large-molecule drugs remains challenging due to poor solubility, perdemeability, and stability in the gastrointestinal...

In the pharmaceutical industry, ensuring the bioavailability of active ingredients is crucial for the effectiveness of orally administered treatments. Bioavailability...

Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4 ng/ mL in water) requires formulation enhancement to achieve...

In recent years, there has been much interest in three-dimensional (3D) printing for the development of personalized and on-demand medications...

Abstract Interest in hot-melt extrusion (HME) and fused deposition material (FDM) printing has increased in recent years, for the production...

Abstract Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of...

Abstract Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble...

Abstract Congenital diaphragmatic hernia (CDH) is a rare disease in which neonates are born with pulmonary hypoplasia and a diaphragmatic...

Abstract Recent developments in pharmacogenetics have emphasised the importance of customised medication, driving interest in technologies like FDM 3D-printing for...

Abstract Background/Objectives: Chagas disease is a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are...