Spray Dried Progesterone Formulations for Carrier Free Dry Powder Inhalation

13. July 2023

Low oral absorption and extensive first pass metabolism of progesterone is reported for many oral formulations which warrants investigation into...

In vitro-in vivo relationship for amorphous solid dispersions using a double membrane dissolution-permeation setup

10. June 2023

The use of amorphous solid dispersions (ASDs) is one commonly applied formulation strategy to improve the oral bioavailability of poorly...

Novel Applications of Hot Melt Extrusion Technology

11. May 2023

Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there...

Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?

2. March 2023

Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting...

The applications of machine learning to predict the forming of chemically stable amorphous solid dispersions prepared by hot-melt extrusion

31. January 2023

Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly...

Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

9. January 2023

PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However,...

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

30. December 2022

Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs...

Time-Based Formulation Strategies for Colon Drug Delivery

26. December 2022

Despite poor absorption properties, delivery to the colon of bioactive compounds administered by the oral route has become a focus...

Exposing Profound Screening Potential of Ethanol-Based Dissolution Media in the Development of Oral-Modified Dosage Forms

15. December 2022

Characterization of drug release from modified-release products in the presence of alcohol is required to evaluate the possibility of dose...

The impact of applying an additional polymer coating on high drug-loaded amorphous solid dispersions layered onto pellets

5. December 2022

Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of amorphous solid dispersions (ASDs), still preserving high...

Hydroxypropyl methylcellulose acetate succinate (HPMCAS)