List of Microcrystalline Cellulose Products and Manufacturers
Discovered in 1955, the excipient microcrystalline cellulose is the most commonly used binder on the pharmaceutical market. It’s popularity comes from its versatility and a huge range of applications. It can bulk, disintegrate, bind, and lubricate. It enhances stability and extends drug release. As a natural, fibre-rich component, it’s nontoxic and chewable. It’s also a favourite among dissolvable drug manufacturers. It’s carved a space for itself as an excipient in both the supplement industry and the potent drug delivery niche. Its scope is not limited to capsules and tablets. It’s used in medicated gels, as well.
Click here to see all of our articles around MCC
| Product Name | Composition | Particles Size, D50µm | Bulk Density | Moisture, % | Features | Manufacturer |
|---|---|---|---|---|---|---|
| Avicel® CE-15 | Microcrystalline Cellulose, Guar Gum | 75 | Improved sensory attributes in chewables | Dupont Pharma | ||
| Avicel® CL-611 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | n/a | Superior gel strength and thixotropic behavior for suspensions | Dupont Pharma | ||
| Avicel® DG | Microcrystalline Cellulose, Dicalcium Phosphate | 45 | Improved compactibility, mainly in dry granulation | Dupont Pharma | ||
| Avicel® HFE-102 | Microcrystalline Cellulose, Mannitol | 100 | Improved flow and decreased lubrication sensitivity | Dupont Pharma | ||
| Avicel® PH-101 | Microcrystalline Cellulose | 50 | 3.0 to 5.0 | Premier Binder | Dupont Pharma | |
| Avicel® PH-102 | Microcrystalline Cellulose | 100 | 3.0 to 5.0 | Premier Binder | Dupont Pharma | |
| AVICEL PH-103 | Microcrystalline Cellulose | 50 | NMT 3 | Low Moisture | Dupont Pharma | |
| Avicel® PH-105 | Microcrystalline Cellulose | 20 | NMT 5.0 | Superior Compactibility | Dupont Pharma | |
| Avicel® PH-112 | Microcrystalline Cellulose | 100 | NMT 1.5 | Low Moisture | Dupont Pharma | |
| Avicel® PH-113 | Microcrystalline Cellulose | 50 | NMT 2 | Low Moisture | Dupont Pharma | |
| Avicel® PH-200 LM | Microcrystalline Cellulose | 180 | NMT 1.5 | Low Moisture | Dupont Pharma | |
| Avicel® PH-200 | Microcrystalline Cellulose | 180 | 2.0 to 5.0 | Superior Flow | Dupont Pharma | |
| Avicel® PH-301 | Microcrystalline Cellulose | 50 | 3.0 to 5.0 | High Density | Dupont Pharma | |
| Avicel® PH-302 | Microcrystalline Cellulose | 100 | 3.0 to 5.0 | High Density | Dupont Pharma | |
| Avicel® RC-591 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | n/a | Superior gel strength and thixotropic behavior for suspensions | Dupont Pharma | ||
| Avicel® SMCC 50 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 50 | Improved flow and compactibility | Dupont Pharma | ||
| Avicel® SMCC 90 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 100 | Improved flow and compactibility | Dupont Pharma | ||
| Avicel® SMCC HD 900 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 100 | Improved flow and compactibility | Dupont Pharma | ||
| MICROCEL™ 101 SD | Microcrystalline Cellulose | 50 µm approx | Optimized for compactibility and wet granulation | Roquette | ||
| MICROCEL™ 102 SD | Microcrystalline Cellulose | 100 µm approx | Optimized for compactibility and direct compression | Roquette | ||
| MICROCEL™ 112 SD | Microcrystalline Cellulose | 100 µm approx | Low moisture content, Very high compactibility | Roquette | ||
| MICROCEL™ 200 SD | Microcrystalline Cellulose | 180 µm approx | Improved flow properties, Very high compactibility, Optimized for direct compression | Roquette | ||
| MICROCEL™ 301 SD | Microcrystalline Cellulose | 50 µm approx | Higher density | Roquette | ||
| MICROCEL™ 302 SD | Microcrystalline Cellulose | 100 µm approx | Higher density | Roquette | ||
| MICROCEL™ MC-12 | Microcrystalline Cellulose | 160 µm approx | Roquette | |||
| MICROCEL™ MC-101 | Microcrystalline Cellulose | 50 µm approx | Optimized for wet granulation | Roquette | ||
| MICROCEL™ MC-102 | Microcrystalline Cellulose | 100 µm approx | Roquette | |||
| MICROCEL™ MC-112 | Microcrystalline Cellulose | 100 µm approx | Low moisture content | Roquette | ||
| MICROCEL™ MC-200 | Microcrystalline Cellulose | 180 µm approx | Designed for direct compression | Roquette | ||
| MICROCEL™ MC-302 | Microcrystalline Cellulose | 100 µm approx | High Density | Roquette | ||
| Avicel® PH-102 SCG | Microcrystalline Cellulose | 150 | 3.0 to 5.0 | Superior Flow | Dupont Pharma | |
| CEOLUS® KG-802 | Microcrystalline Cellulose | 50 | 0.21 | 2.0-6.0 | The key to the compactibility of the CEOLUS KG grades lies in their needle-like particle shape. Needle-like particles, once compressed, have less elastic recovery and moreparticle-to-particle entanglements to provide greater tablet hardness. | Asahi Kasei |
| CEOLUS® KG-1000 | Microcrystalline Cellulose | 50 | 0.12 | 2.0-6.0 | KG-1000, offers practically required tablet hardness and friability at concentrations of 10% or less. | Asahi Kasei |
| CEOLUS® PH-101 | Microcrystalline Cellulose | 50 | 0.29 | 2.0-5.0 | Standard grade. Most widely used for wet granulation tableting. | Asahi Kasei |
| CEOLUS® PH-102 | Microcrystalline Cellulose | 90 | 0.30 | 2.0-5.0 | Larger particle size. Improved flow while maintaining compactibility and distintegration properties similar to PH-101. Used mostly for direct compression tableting. | Asahi Kasei |
| CEOLUS® PH-200 | Microcrystalline Cellulose | 170 | 0.35 | 2.0-6.0 | Larger particle size than PH-102. Increased flow. | Asahi Kasei |
| CEOLUS® PH-301 | Microcrystalline Cellulose | 50 | 0.41 | 2.0-6.0 | Higher bulk density than PH-101. Improved flow and disintegration. | Asahi Kasei |
| CEOLUS® PH-302 | Microcrystalline Cellulose | 90 | 0.43 | 2.0-6.0 | Larger particle size than PH-301 with similar compactibility and disintegration properties to PH-301. Increased flow. | Asahi Kasei |
| CEOLUS® PH-F20JP | Microcrystalline Microcrystalline Cellulose | 20 | 0.23 | Not more than 7.0 | Smallest particle size with increased surface area for enhanced compactibility. | Asahi Kasei |
| CEOLUS® UF-702 | Microcrystalline Cellulose | 90 | 0.29 | 2.0-6.0 | The porous structures and more spherical morphology of CEOLUS UF grades contribute to their effective plastic deformation and better flow. They are highly compactible and flowable. | Asahi Kasei |
| CEOLUS® UF-711 | Microcrystalline Cellulose | 50 | 0.22 | 2.0-6.0 | The porous structures and more spherical morphology of CEOLUS UF grades contribute to their effective plastic deformation and better flow. They are highly compactible and flowable. | Asahi Kasei |
| Comprecel® M101 | Microcrystalline Cellulose | 45 - 75 | 0.26 - 0.34 | NMT 7.0 | Fine particle standard type, providing excellent tablet hardness, and low friability with superior binder capacity. Suitable for wet granulation, roller compaction, direct compression and spheronization. | Mingtai |
| Comprecel® M102 | Microcrystalline Cellulose | 90 - 140 | 0.28 - 0.35 | NMT 7.0 | Standard type of coarser particle size than M101 with improved flowability property, especially suitable for direct compression production. | Mingtai |
| Comprecel® M101LD | Microcrystalline Cellulose | 45 - 75 | 0.14 - 0.24 | NMT 7.0 | Mingtai | |
| Comprecel® M103 | Microcrystalline Cellulose | 45 - 75 | 0.26 - 0.34 | NMT 3.0 | Similar type to M101, but with lower moisture content for water-sensitive active ingredients. | Mingtai |
| Comprecel® M105 | Microcrystalline Cellulose | 17 - 27 | 0.20 - 0.30 | NMT 7.0 | Finest particle size type and most compressible of MCC products; suitable for roller compaction as well as direct compression to enhance tablet hardness | Mingtai |
| Comprecel® M112 | Microcrystalline Cellulose | 90 - 140 | 0.28 - 0.37 | NMT 1.5 | Equivalent type to M102 in many physical properties, but with extremely lower moisture content designed for moisture sensitive active ingredients. | Mingtai |
| Comprecel® M113 | Microcrystalline Cellulose | 45 - 75 | 0.26 - 0.34 | NMT 2.0 | Similar type to M101, but with lower moisture content than M101 and M103. It is recommended for moisture sensitive active ingredients. | Mingtai |
| Comprecel® M200 | Microcrystalline Cellulose | 150 - 280 | 0.32 - 0.42 | NMT 7.0 | Coarsest type in particle size. It facilitates high speed tabletting and low tablet weight variation due to its excellent flowability. It is recommended for direct compression and hard capsules. It can be also added extra-granular to dry and wet granulation to further enhance mix compressibility. | Mingtai |
| Comprecel® M200LM | Microcrystalline Cellulose | 140 - 250 | 0.32 - 0.42 | NMT 2.0 | Mingtai | |
| Comprecel® M212 | Microcrystalline Cellulose | 140 - 180 | 0.30 - 0.36 | NMT 7.0 | Intermediate particle size between M102 and M200 combining excellent binding capacity with good flow properties; suitable for direct compression with good content uniformity. | Mingtai |
| Comprecel® M301 | Microcrystalline Cellulose | 45 - 75 | 0.34 - 0.45 | NMT 7.0 | Higher bulk density versions of M101 and M102; improves production efficiency by allowing for increased batch size in blending. They also facilitate reduced tablet weight variation at higher tablet speed. Suitable for direct compression, especially design for thinner tablets in the presence of low density ingredients. | Mingtai |
| Comprecel® M302 | Microcrystalline Cellulose | 90 - 140 | 0.35 - 0.46 | NMT 7.0 | Higher bulk density versions of M101 and M102; improves production efficiency by allowing for increased batch size in blending. They also facilitate reduced tablet weight variation at higher tablet speed. Suitable for direct compression, especially design for thinner tablets in the presence of low density ingredients. | Mingtai |
| Comprecel® SMCC 50 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 45 – 80 | 0.25 – 0.37 | NMT 7.0 | Corresponding to M101 - Improved Compactibility, Enhanced flow, Less sensitive for lubrication, Dust-reduced Handling in production | Mingtai |
| Comprecel® SMCC 90 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 90 - 150 | 0.25 - 0.37 | NMT 7.0 | Corresponding to M102 - Improved Compactibility, Enhanced flow, Less sensitive for lubrication, Dust-reduced Handling in production | Mingtai |
| Comprecel® SMCC 90HD | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 90 - 150 | 0.38 – 0.50 | NMT 7.0 | Corresponding to M302 - Improved Compactibility, Enhanced flow, Less sensitive for lubrication, Dust-reduced Handling in production | Mingtai |
| Comprecel® SMCC 90LM | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 90 - 150 | 0.27 – 0.39 | NMT 3.0 | Corresponding to M112 - Improved Compactibility, Enhanced flow, Less sensitive for lubrication, Dust-reduced Handling in production | Mingtai |
| Pharmacel® 101 | Microcrystalline Cellulose | 60 | Strong binder for wet and dry granulation | DFE Pharma | ||
| Pharmacel® 102 | Microcrystalline Cellulose | 90 | Strong binder for wet and dry granulation | DFE Pharma | ||
| Pharmacel® 112 | Microcrystalline Cellulose | 90 | Suitable for water sensitive drugs | DFE Pharma | ||
| PROSOLV® SMCC 50 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 65 | 0.25 – 0.37 | Formulas in which optimal compaction and decent flow is required | JRS Pharma | |
| PROSOLV® SMCC 50 LD | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 50 | 0.20 – 0.30 | Best in class binder. | JRS Pharma | |
| PROSOLV® SMCC 90 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 125 | 0.25 – 0.37 | Formulas in which a balance of flow and compaction is required. | JRS Pharma | |
| PROSOLV® SMCC 90 LM | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 125 | 0.27 – 0.39 | Equivalent to quality of PROSOLV® SMCC 90, but with lower moisture content (< 3%) | JRS Pharma | |
| PROSOLV® SMCC HD 90 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 125 | 0.38 – 0.50 | Formulas in which optimal flow and consolidation is required. This grade shows the best disintegration times. *Low moisture grade available on request. | JRS Pharma | |
| TABULOSE® SC 200 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | Medium viscosity suspending properties | Roquette | |||
| TABULOSE® SC 591 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | Low viscosity suspending properties | Roquette | |||
| TABULOSE® SC 591F | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | Low viscosity suspending properties | Roquette | |||
| TABULOSE® SC 611 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | Very low viscosity suspending properties | Roquette | |||
| TABULOSE® SC 681 | Microcrystalline Cellulose, Carboxymethyl Cellulose Sodium | High viscosity, High suspending properties | Roquette | |||
| VIVAPUR® 105 | Microcrystalline Cellulose | 15 | max 0.26 | Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes and supports flavors. | JRS Pharma | |
| VIVAPUR® 101 | Microcrystalline Cellulose | 65 | 0.26 – 0.31 | Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility. | JRS Pharma | |
| VIVAPUR® 103 | Microcrystalline Cellulose | 65 | 0.26 – 0.34 | Same quality as grade 101/50M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. | JRS Pharma | |
| VIVAPUR® 301 | Microcrystalline Cellulose | 65 | 0.35 – 0.46 | Same quality as grade 101, but increased bulk density and improved flow properties. | JRS Pharma | |
| VIVAPUR® 102 | Microcrystalline Cellulose | 130 | 0.28 – 0.33 | Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility. | JRS Pharma | |
| VIVAPUR® 112 | Microcrystalline Cellulose | 130 | 0.30 – 0.36 | Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives | JRS Pharma | |
| VIVAPUR® 302 | Microcrystalline Cellulose | 130 | 0.35 – 0.50 | Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives. | JRS Pharma | |
| VIVAPUR® 102 SCG | Microcrystalline Cellulose | 170/175 | 0.28 – 0.34 | Coarse, DC-grade MCC. | JRS Pharma | |
| VIVAPUR® 12 | Microcrystalline Cellulose | 180 | 0.30 – 0.36 | Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives. | JRS Pharma | |
| VIVAPUR® 14 | Microcrystalline Cellulose | 170 | 0.32 – 0.40 | Same quality to grade 12, but very low moisture content (<1.5 %) for processing water-sensitive actives. | JRS Pharma | |
| VIVAPUR® 200 | Microcrystalline Cellulose | 250 | 0.31 – 0.37 | Large size MCC grade with excellent flow properties for a variety of direct compression formulations. | JRS Pharma | |
| VIVAPUR® 200 XLM | Microcrystalline Cellulose | 250 | 0.33 – 0.40 | Same quality to grades 200/LP200, but very low moisture content (<1.5 %) for processing water-sensitive actives. | JRS Pharma | |
| Primecel™ PH-101 | Microcrystalline Cellulose | 50 | 0.26-0.31 | NMT 5.0 | Wet Granulation and Compactibility | Chemfield Cellulose |
| Primecel™ PH-102 | Microcrystalline Cellulose | 100 | 0.28-0.33 | NMT 5.0 | Direct Compression and Compactibility | Chemfield Cellulose |
| Primecel™ PH-102LM | Microcrystalline Cellulose | 100 | 0.28-0.33 | NMT 3.0 | Low Moisture | Chemfield Cellulose |
| Primecel™ PH-103 | Microcrystalline Cellulose | 50 | 0.26-0.31 | NMT 3.0 | Low Moisture | Chemfield Cellulose |
| Primecel™ PH-112 | Microcrystalline Cellulose | 100 | 0.28-0.33 | NMT 1.5 | Low Moisture | Chemfield Cellulose |
| Primecel™ PH-200 | Microcrystalline Cellulose | 200 | 0.28-0.36 | NMT 5.0 | Increased Flowability and Direct Compression | Chemfield Cellulose |
| Primecel™ PH-301 | Microcrystalline Cellulose | 50 | 0.33-0.40 | NMT 5.0 | High Density | Chemfield Cellulose |
| Primecel™ PH-302 | Microcrystalline Cellulose | 100 | 0.33-0.40 | NMT 5.0 | High Density | Chemfield Cellulose |
| Chemicel™ PH-101 | Microcrystalline Cellulose | 50 | 0.26-0.33 | NMT 6.0 | Wet Granulation and Compactibility | Chemfield Cellulose |
| Chemicel™ PH-102 | Microcrystalline Cellulose | 100 | 0.26-0.33 | NMT 6.0 | Direct Compression and Compactibility | Chemfield Cellulose |
| Chemicel™ PH-102LM | Microcrystalline Cellulose | 100 | 0.26-0.33 | NMT 3.0 | Low Moisture | Chemfield Cellulose |
| Chemicel™ PH-103 | Microcrystalline Cellulose | 50 | 0.26-0.33 | NMT 3.0 | Low Moisture | Chemfield Cellulose |
| Chemicel™ PH-112 | Microcrystalline Cellulose | 100 | 0.26-0.33 | NMT 2.0 | Low Moisture | Chemfield Cellulose |
| Chemicel™ PH-200 | Microcrystalline Cellulose | 170 | 0.28-0.36 | NMT 6.0 | Increased Flowability and Direct Compression | Chemfield Cellulose |
| Chemicel™ PH-301 | Microcrystalline Cellulose | 50 | 0.33-0.40 | NMT 6.0 | High Density | Chemfield Cellulose |
| Chemicel™ PH-302 | Microcrystalline Cellulose | 100 | 0.33-0.40 | NMT 6.0 | High Density | Chemfield Cellulose |
| Primesolv™ SMCC-50 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 60 | 0.25-0.37 | NMT 6.0 | Improved Flow and Compactibility | Chemfield Cellulose |
| Primesolv™ SMCC-90 | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 110 | 0.25-0.37 | NMT 6.0 | Improved Flow and Compactibility | Chemfield Cellulose |
| Primesolv™ SMCC-90HD | Microcrystalline Cellulose, Colloidal Silicon Dioxide | 110 | 0.38-0.50 | NMT 6.0 | Improved Flow and Compactibility | Chemfield Cellulose |