Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation
Abstract
Background
This study aimed to formulate solid self-nanoemulsifying drug delivery systems (SNEDDS) for nimodipine (NIM). The selection of Cremophor RH 40, Lipoxol 300, and PEG 400 as oil, surfactant, and co-surfactant was based on solubility and self-emulsification assessments. A ternary phase diagram determined the optimal oil to Smix…
Development of 3D-printed dual-release fixed-dose combination through double-melt extrusion
This study aimed to develop a 3D-printed fixed-dose combination tablet featuring differential release of two drugs using double-melt extrusion (DME). The hot-melt extrusion (HME) process was divided into two steps to manufacture a single…
Stability of Free and Liposomal Encapsulated RNA on a Mucoadhesive PVA Polymer for Esophageal RNA…
Abstract
The development of RNA and oligonucleotide-based therapeutics is a longstanding goal and is currently gaining significant attention. Several RNA-based drugs are approved for clinical use. Others are under investigation or in…
Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and…
Abstract
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems. In particular, the introduction of…
Quantification of Soluplus for Dissolution Tests: SEC Method Development and Validation
The quantification of both polymer and drug during the dissolution of an amorphous solid dispersion (ASD) in aqueous media arouses great interest and may aid in the formulation. However, the available quantification methods for polymer…
Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug…
Abstract
Ketoprofen is a non-steroidal, anti-inflammatory drug frequently incorporated in topical dosage forms which are an interesting alternatives for oral formulations. However, due to the physiological barrier function of skin, topical…
Regulations on excipients used in 3D printing of pediatric oral forms
Abstract
A promising solution to customize oral drug formulations for the pediatric population has been found in the use of 3D printing, in particular Fused Deposition Modeling (FDM) and Semi-Solid Extrusion (SSE). Although formulation…
3D printed electro-responsive system with programmable drug release
Abstract
Precision medicine is the next frontier in pharmaceutical research, aiming to improve the safety and efficacy of therapeutics for patients. The ideal drug delivery system (DDS) should be programmable to provide real-time…
Acceptability of compounded preparations – A Romanian pediatric hospital perspective
Abstract
Compounded medicines are widely used, especially for pediatric patients. The aim of this study was to evaluate children’s acceptability of compounded preparations and to provide information regarding compounding practices'…
In-situ monitoring of in vitro drug release processes in tablets using optical coherence tomography
Film-coated modified-release tablets are an important dosage form amenable to targeted, controlled, or delayed drug release in the specific region of the gastrointestinal (GI) tract. Depending on the film composition and interaction with…
Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization aid was investigated. Furthermore, the impact of cations on extrusion-spheronization (ES)…
Colon targeting in rats, dogs and IBD patients with species-independent film coatings
Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides are degraded…
New Croda product range Virodex™: Replacements to Triton™ X-100
Triton™ X-100 is used widely in the biopharmaceutical industry for virus inactivation and cell lysis applications. While the performance of Triton™ X-100 cannot be challenged, the detergent is associated with a number of disadvantages, with…
Unveiling the Mystery of Soft Gelatin Capsules
Soft Gelatin Capsules (SGCs), commonly known as softgels, have transformed drug delivery since their invention. Despite their 19th-century origins, their widespread adoption only began in the 20th century, thanks to technological…
3D printed scaffolds as delivery devices for nanocrystals: A proof of concept loading Atorvastatin…
Abstract
Increasing the solubility of drugs is a recurrent objective of pharmaceutical research, and one of the most widespread strategies today is the formulation of nanocrystals (NCs). Beyond the many advantages of formulating NCs,…
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing…
Abstract
Process intensification involves the miniaturization of equipment while retaining process throughput and performance. The pharmaceutical industry can benefit from this approach especially during drug product development, where…
A two-phase flow model simulating water penetration into pharmaceutical tablets
The purpose of the study is introduce a two-phase flow model to simulate water penetration into pharmaceutical tablets. This model was built by integrating Darcy’s law with the continuity principle, on the premise that water penetration was…
Polymeric Microneedles Enhance Transdermal Delivery of Therapeutics
This research presents the efficacy of polymeric microneedles in improving the transdermal permeation of methotrexate across human skin. These microneedles were fabricated from PLGA Expansorb® 50-2A and 50-8A and subjected to comprehensive…
Mucoadhesive aprepitant-loaded nanostructured lipid carriers containing sulfhydryl surfactant for…
The objective of the study was to design mucoadhesive drug-loaded nanostructured lipid carriers (NLCs) for enhancing the bioavailability of a model BCS Class IV drug aprepitant (APT). For this purpose, polyethoxylated surfactant…
Microfluidic preparation and optimization of Kollicoat ® IR-b-PCL polymersome for co-delivery of…
Abstract
This work aimed to develop amphiphilic nanocarriers such as polymersome based diblock copolymer of Kollicoat ® IR −block-poly(ε-caprolactone) (Kollicoat ® IR-b-PCL) for potential co-delivery of Nisin (Ni) and Curcumin (CUR) for…
Labrafac MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with…
Labrafac™ MC60 (glycerol monocaprylocaprate) is a lipid-based excipient used in oral formulations as a solubiliser. Due to the high proportions of established permeability enhancers, caprylate (C8) and caprate (C10), in Labrafac™ MC60, we…
Nucleotides as new co-formers in co-amorphous systems: Enhanced dissolution rate, water solubility…
Abstract
Developing co-amorphous systems is an attractive strategy to improve the dissolution rate of poorly water-soluble drugs. Various co-formers have been investigated. However, previous studies revealed that it is a challenge to…
Improvement of lidocaine skin permeation by using passive and active enhancer methods
Lidocaine is generally recognized and preferred for local anaesthesia, but in addition, studies have described additional benefits of lidocaine in cancer therapy, inflammation reduction, and wound healing. These properties contribute to its…
Design and evaluation of oseltamivir phosphate dual-phase extended-release tablets for the treatment…
Abstract
In this study, once-daily extended-release tablets with dual-phase release of oseltamivir phosphate were developed for the treatment of influenza. The goal was to improve patient adherence and offer more therapeutic choices. The…
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl…
Hot-melt extrusion (HME) potentially coupled with 3D printing is a promising technique for the manufacturing of dosage forms such as drug-eluting implants which might even be individually adapted to patient-specific anatomy. However, these…
Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and…
Chemically cross-linked hydrogel nanoparticles (HGNPs) offer enhanced properties over their physical counterparts, particularly in drug delivery and cell encapsulation. This study applied pH-thermal dual responsive bio-adhesive HGNPs for…
The effect of material properties and process parameters on die filling at varying throughputs: A…
Abstract
When tablets are manufactured on a rotary tablet press and the throughput is increased, it leads to changes in powder dynamics during die filling due to formulation characteristics and changing powder flow in the feed frame.…
Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to…
Parkinson's disease (PD), affecting about ten million people globally, presents a significant health challenge. Rotigotine (RTG), a dopamine agonist, is currently administered as a transdermal patch (Neupro®) for PD treatment, but the daily…
Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug…
Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic metabolism. The aim of this study was to explore the potential of employing Hot Melt Extrusion (HME)…
Comparison of two self-nanoemulsifying drug delivery systems using different solidification…
In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid self-nanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved…
Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut stability and solubility remain challenges to be addressed…
Tablet ejection: A systematic comparison between force, static friction, and kinetic friction
The magnitude of the frictional forces during the ejection of porous pharmaceutical tablets plays an important role in determining the occurrence of tabletting defects. Here, we perform a systematic comparison between the maximum ejection…
Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation,…
Drug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent. However,…
Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug…
Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material…