Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused Deposition Modelling
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial to enable three-dimensional printing (3DP). Hence,…
Application on the Direct Encapsulation Method in the Technology of Medicine with Dry Rauwolphia…
Abstract
The aim: Development of the composition and technology of a medicinal drug in the form of capsules with a dry
extract of Rauwolfia for the treatment of hypertension.
Materials and methods: Experimental samples of masses for…
Comparison of Berberine Bioavailability between Oral and Rectal Administrations in Rats
Abstract
The oral bioavailability of berberine is quite low due to extensive first-pass metabolism. To increase the bioavailability of berberine (BBR), the efficacy of rectal administration that can avoid intestinal and hepatic first-pass…
Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
D-limonene, derived from citrus essential oils, holds significant therapeutic potential but faces challenges due to its high volatility, especially in pharmaceutical formulations. This study investigates microemulsions as a promising…
In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but…
Functionalized calcium carbonate (FCC) as a novel carrier to solidify supersaturated…
Functionalized calcium carbonate (FCC), a novel pharmaceutical excipient, has shown promising properties in the field of oral drug delivery. The current study aimed at evaluating the feasibility of FCC as a carrier for the solidification of…
Exploring new ways to produce cosmetic pigments – Interview with Merck and Glatt about the…
Using completely new technology, pigment specialists at Merck and Glatt Ingenieurtechnik’s technology and production experts have worked closely together to produce an innovative range of cosmetic pigments. The Darmstadt-based Merck Group…
Smart pills and drug delivery devices enabling next generation oral dosage forms
Oral dosage forms are the preferred solution for systemic treatment and prevention of disease conditions. However, traditional dosage forms face challenges regarding treatment adherence and delivery of biologics. Oral therapies that require…
Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with…
This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the…
Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting…
Abstract
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared…
Roquette Introduced New Chapter in Moisture Protection at CPhI 2023
Press Release
La Madeleine (France), 25th October 2023 – Roquette, a global leader in plant-based ingredients and leading provider of pharmaceutical and nutraceutical excipients, is pleased to announce the addition of three new excipient…
Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and…
Abstract
We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to visualize water penetration through the porous network of immediate-release pharmaceutical solid tablets and characterize dynamic swelling and…
Optimizing environmental sustainability in pharmaceutical 3D printing through machine learning
Abstract
3D Printing (3DP) of pharmaceuticals could drastically transform the manufacturing of medicines and facilitate the widespread availability of personalised healthcare. However, with increasing awareness of the environmental damage…
MeltSerts Technology (Brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development,…
The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central…
Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple…
Combining the potential of 3D printed buccal films and nanostructured lipid carriers for…
Abstract
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and…
Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability…
Abstract
Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by…
A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of…
Abstract
The goal of the present work was to develop an in vitro toolbox to evaluate the oral administration of dosage forms to children of different age groups and under different administration conditions (fasted/fed). Based on current…
Phospholipids for Advanced OTC Formulations
Phospholipids are amphiphilic, endogenous molecules with excellent biocompatibility and tolerability. Therefore, they are an ideal choice for various “over-the-counter” (OTC) products, including formulations for sensitive tissue such as the…
Application of Response Surface Methodology to Improve the Tableting Properties of Poorly…
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow…
The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration…
Bioactive chemlali olive derivatives and compounds useful for pharmaceutical purposes: A review
Several articles in the literature deal with and analyze components extracted from the olive tree, but these researches are mainly focused on the quality of olive oil and more precisely its volatile components, often related to their…
Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with…
Abstract
The therapeutic effectiveness of paliperidone in the treatment of schizophrenia has been limited by its poor oral bioavailability; hence, an alternative route could be appropriate. This study investigates the feasibility of…
Scale-up in Twin-screw wet granulation: Impact of formulation properties
The focus of this study was to investigate the sensitivity of different drug formulations to differences in process parameters based on previously developed scale-up strategies. Three different formulations were used for scale-up…
Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori…
Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in…
Drug Dissolution in Oral Drug Absorption: Workshop Report
Abstract
The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout sessions. Three common topics that were re-visited by…
Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled…
Tailoring Dry Microparticles for Pulmonary Drug Delivery: Ultrasonic Spray Freeze-Drying with…
Abstract
Spray freeze-drying has emerged as a valid alternative to traditional spray drying to produce therapeutic dry microparticles. In particular, the spherical shape and high porosity of spray freeze-dried microparticles make them…
Handbook of Post-Processing in Additive Manufacturing – Part 2
Handbook of Post-Processing in Additive Manufacturing
See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh.
Description: Handbook of Post-Processing in Additive Manufacturing is a key…
The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of…
The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate…
Development, Characterization, and Ex Vivo Permeation Assessment of Diclofenac Diethylamine Deep…
Abstract
Purpose
The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems (THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac diethylamine (DDEA), a non-steroidal…
Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of…
Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics…
Pullulan hydrogels as drug release platforms in biomedicine
It is increasingly urgent to develop new therapeutic systems to combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder the patient's recovery. In…
Extrusion-based technologies for 3D printing: a comparative study of the processability of…
Thermoplastic polyurethanes (TPU) offer excellent properties for a wide range of dosage forms. These polymers have been successfully utilized in personalized medicine production using fused deposition modeling (FDM) 3D printing (3DP).…
Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic…
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated in situ during ASD dissolution…