Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles

Chemically cross-linked hydrogel nanoparticles (HGNPs) offer enhanced properties over their physical counterparts, particularly in drug delivery and cell encapsulation. This study applied pH-thermal dual responsive bio-adhesive HGNPs for dual complexation and enhanced the controlled release and bioavailability of cisplatin (CDDP) and Vitamin E (VE) drugs. The CDDP was loaded into the HGNPs via chemical conjugation with the carboxyl groups in the HGNPs surface by soy polysaccharides (SSPS).

Highlights

• The β-CD crosslinked soy polysaccharides for dual encapsulation and sequential release.
• The hydrogel nanoparticles showed the ability of hydrophilic and hydrophobic drug delivery.
• The FTIR, XRD, XPS, and zeta potential confirmed the conjugation.
• The HGNPs exhibited longer circulation time in vitro and in vivo.
• At pH 1.2, the cumulative release percentage of cisplatin was 98 %.

At the same time, the host-guest interaction complexed the VE through the β-cyclodextrin (β-CD). The HGNPs showed a uniform HGNPs size distribution of 90.77 ± 14.77 nm and 81.425 ± 13.21 nm before and after complexation, respectively. The FTIR, XRD, XPS, and zeta potential confirmed the conjugation. The cumulative release percent of CDDP reached 98 % at pH 1.2, while <45 % was released at pH 7.4.

Our HGNPs enhance the incorporation of CDDP by substituting its chlorides with carboxyl groups of the SSPS; the loading of CDDP and VE was 15 ± 0.33 and 11.32 ± 0.25 wt%, respectively. Moreover, the CDDP and VE also released slower from the HGNPs at 25 °C than at 37 °C and 42 °C. The (VE/CDDP)-loaded HGNPs exhibited longer circulation time in vivo than free CDDP and free VE suspension.

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Materials

β-cyclodextrin ≥97 % was dried at 80 °C over three days before use, molecular weight (MW) 1134.98 g/mol, Sigma Aldrich, USA). Soy polysaccharides (98 %) obtained from (FU JI OIL Biological Technology Trading Co., Ltd., Beijing, China), the methyl esterification degree (DM) and galacturonic acid were determined in this study in the supporting information as 6.844 % and 18 % (w/w), respectively, Fig. S1.

Mohamed Eid, Jingsong Zhu, Muhammad Asif Ismail, Bin Li, Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles, International Journal of Biological Macromolecules, Volume 273, Part 2, 2024, 133240, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.133240.

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