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COVID-19
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate…
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2…
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Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass spectrometry was used for the discovery of botanical ligands to the…
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Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and…
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2…
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Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm
Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time. Current study attempts to apply computational methods to accelerate the LNP development…
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The polysorbate containing AstraZeneca COVID-19 vaccine is tolerated by polyethylene glycol (PEG)…
Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. We previously demonstrated PEG allergy was a cause of severe anaphylaxis to the Pfizer/BioNTech COVID-19 vaccine. PEG is widely used in many household products, cosmetics and medicines. However PEG allergy is rare, there…
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Developing mRNA for therapy – Not Warp Speed – Reichstein Award Lecture 2021 by Prof.…
It is the stated goal of SAPhS to promote pharmaceutical sciences and scientists. This includes promoting their perception and recognition among the population. The awarding of the Reichstein Medal should contribute to this. It is reminiscent of the merits of the Swiss chemist and Nobel Prize winner…
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Clinical translation of silica nanoparticles
Silica nanoparticles have entered clinical trials for a variety of biomedical applications, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy. Preliminary results indicate the safety, efficacy and viability of silica nanoparticles under these…
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New Glatt webinar: The impact of coronavirus on comparator sourcing in clinical trials
Monday, 18 October 2021 – 03:00 PM CEST | 09:00 AM EST
In this presentation there will be a critical review of the impact that the Coronavirus pandemic has had on comparator studies and to a lesser extent clinical trials in general.
We will review ongoing studies seeking to identify potential…
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Lipid Nanoparticles – From Liposomes to mRNA Vaccine Delivery, a Landscape of Research…
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells.…
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The investigation of mRNA vaccines formulated in liposomes administrated in multiple routes against…
COVID-19 pandemic has resulted in an unprecedented global public health crisis. It is obvious that SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Since obvious advantages including fast manufacturing speed, potent immunogenicity and good safety profile, six mRNA…
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