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COVID-19
Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces…
Novel Coronavirus is affecting human's life globally and vaccines are one of the most effective ways to combat the epidemic. Transcutaneous immunization based on microneedle (MN) has attracted much attention because of its painlessness, rapidity, high efficiency and good compliance. In this study,…
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Can Liposomes Survive Inkjet Printing? The Effect of Jetting on Key Liposome Attributes for Drug…
Purpose
Inkjet printing has the potential to enable novel personalized and tailored drug therapies based on liposome and lipid nanoparticles. However, due to the significant shear force exerted on the jetted fluids, its suitability for shear-sensitive materials such as liposomes, has not been…
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Better fat bubbles could power a new generation of mRNA vaccines
New lipid delivery systems aim to improve potency and reduce side effects
As any dietician will tell you, some fats are good—and that is surely true of the little fatty balls found in two of the world’s most widely used COVID-19 vaccines. Known as lipid nanoparticles (LNPs), these tiny bubbles of…
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An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties…
The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines, Comirnaty® (Pfizer/BioNtech) and Spikevax® (Moderna), in the context of the Covid-19 crisis. Safe and effective delivery systems are essential to the…
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UK Government to support expansion of Croda’s lipid systems manufacturing facility
Croda International Plc that uses smart science to create high performance ingredients and solutions that improve lives, announces that it has been awarded a £15.9 million grant by the UK Government to expand its manufacturing facility in Leek, Staffordshire. The investment will significantly…
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Can pulmonary RNA delivery improve our pandemic preparedness?
The coronavirus pandemic has changed our perception of RNA medicines, and RNA vaccines have revolutionized our pandemic preparedness. But are we indeed prepared for the next variant or the next emerging virus? How can we prepare? And what does the role of inhaled antiviral RNA play in this regard?…
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Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy
Ivermectin has received worldwide attention as a potential COVID-19 treatment after showing antiviral activity against SARS-CoV-2 in vitro. However, the pharmacokinetic limitations associated with oral administration have been postulated as limiting factors to its bioavailability and efficacy. These…
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Evonik increases global supply of pharma-grade plant-derived cholesterol for mRNA vaccines and gene…
Extra production capacity for PhytoChol® at German site
Meets increasing demand for critical lipid used in mRNA vaccines, gene therapies and other parenteral applications
Strengthens Evonik’s position as system solutions provider for the pharma and biotech industries
Essen,…
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Taking leads out of nature, can nano deliver us from COVID-like pandemics?
The COVID-19 crisis has alerted the research community to re-purpose scientific tools that can effectively manage emergency pandemic situations. Researchers were never so desperate to discover a 'magic bullet' that has significant clinical benefits with minimal or no side effects. At the beginning…
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The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency
The efficacy of RNA-based vaccines has been recently demonstrated, leading to the use of mRNA-based COVID-19 vaccines. The application of self-amplifying mRNA within these formulations may offer further enhancement to these vaccines, as self-amplifying mRNA replicons enable longer expression…
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