Different types, applications and limits of enabling excipients of pharmaceutical dosage forms

Very interesting article in ScienceDirect with overview tables on different API and excipient combinations. The article includes also a list of products with marketing authorizations.

 

Along with the development of novel drug delivery systems the material science is also advancing. Conventional and novel synthetic or natural excipients provide opportunities to design dosage forms of the required features including their bioavailability. Emerging trends in the design and development of drug products indicate an increasing need for the functionality-related characterization of excipients. The purpose of this review is to provide an overview of different types of excipients in relation to their application possibilities in various dosage forms with special focus on the enabling excipients. The study also summarizes the applied excipient systems of research formulations and dosage forms available on the market.

 

Summary

Excipients are essential components of most pharmaceutical dosage forms having a number of biopharmaceutical implications for the drug products. Therefore, their selection should focus on biopharmaceutical, pharmaceutical processing and stabilising perspectives, as well.

The review provides an overview about the diversity of structural properties in relation to their functionality-related characteristics. Practical examples are presented for their role in both research preparations and marketing authorized products, as well. The limit of their use is also described through practical examples.

 

Original Science Direct Article: https://www.sciencedirect.com/science/article/pii/S1740674917300379

Snapshot of "Table I: Different types, applications and limits of enabling excipients of pharmaceutical dosage forms"  www.sciencedirect.com
Snapshot of „Table I: Different types, applications and limits of enabling excipients of pharmaceutical dosage forms“ www.sciencedirect.com

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