Crystallization induced flower-like lactose as potential carriers for dry powder inhaler application
The study documents the flower-like lactose particles as potential carriers to improve Dry Powder Inhaler (DPI) efficiency. The lactose particles (LMx, LMf) are prepared by anti-solvent crystallization and compared with commercial lactose carriers (Inhalac 251; LMc). Formulations of 1.48% w/w drug loading are prepared using salbutamol sulfate (model drug) and different lactose carriers.
Highlights
- • Crystallization induced flower-like lactose gives high %FPF than commercial lactose.
- • Flower-like lactose particles are potential inhalable carriers for DPI application.
- • Particle, bulk property and %FPF are correlated using principal component analysis.
- • High %FPF is due to higher surface roughness, energy and % fine lactose particles.
The carrier properties are correlated with %FPF using principal component analysis. The analytical results confirm LMx is α-lactose monohydrate, LMf comprises α and β-lactose. Time-resolved crystal growth shows that the LMx particle is agglomerated structure while, LMf particle appear as flower-like structure of size (~45.37–63.92 μm) with high surface and aerodynamic properties compared to LMc. The in-vitro aerosolization studies resulted in higher fine particle fraction (%FPF) for formulations with LMx (~33.23%) and LMf (~44.85%) compared to LMc (~23.40%). The high %FPF is mainly attributed to the higher surface roughness, amorphicity, surface energy of engineered lactose carriers.
Neetu Varun, Chinmay Ghoroi,
Crystallization induced flower-like lactose as potential carriers for dry powder inhaler application,
Powder Technology, 2022, 117391, ISSN 0032-5910,
https://doi.org/10.1016/j.powtec.2022.117391.