HME as Advanced Approach for Development of Solid Self Emulsifying Drug Delivery System

The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology’s promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot melt extrusion (HME) technology is increasingly being used for novel applications. Because it has low-cost scale-up capabilities and process automation, which reduce labour costs and capital expenditure. HME has become a crucial technique for pharmaceutical manufacturing and research applications involving drug delivery. In the development of new drug delivery systems, the novel use of the HME method offers a promising alternate strategy. Through a discussion of pertinent case studies, the current review examines the value of HME in the creation of innovative drug delivery systems.

Table 1: Solidification of Liquid self-emulsifying drug delivery by different technique

DapsonAerosilDevelopment of solid self-microemulsifying drug
delivery (S-SMEDDS) of dapsone (DP) by adsorbing
on neusilin US2 and spray drying with aerosil 200.
The optimized formulation of LSMEDDS (F8)
containing capryol 90 (10 percent w/w), Tween 80
(67.5/5 w/w), and labrasol (22.5 percent w/w) showed
the smallest particle size and (10.3) and Solid SEEDS
particle size 87.5 ± 4.95 with yield 30.6% to 42.66%.
Spray drying(Mahore et
al., 2021)
ResveratrolColloidal silicone dioxideA solid self-emulsifying drug delivery systems was
developed by using the spray-drying approach, to
increase the solubility of resveratrol (RES). Three
surfactant systems, soy phosphatidylcholine (SPC),
eumulgin® HRE-40 (EU), and sodium oleate (system
A); SPC/Tween®80 (TW) and sodium oleate (system
B); and SPC/EU/TW (System C), were tested along
with cod liver oil. System C produced the highest
incorporation (21.26 mg/ml). The highest yield solid
self-emulsifying drug delivery systems (80.12) were
made with colloidal silicon dioxide (CSD).
Spray drying(Aloisio et al.,
To create a novel solid self-microemulsifying drug
delivery system (SMEDDS) that contains
methotrexate (MTX) and has improved bioavailability
and photostability. Spray drying liquid SMEDDS with the solid carrier produced the solid SMEDDS. The
liquid SMEDDS droplet size of 189.336.61 nm and
the solid reconstituted particle size of 126.734.32 nm
were used to optimize the formulation.
Spray drying(Kim et al.,
Bambuterol hydrochlorideMicrocrystalline cellulose: aerosilThe solid self-emulsifying drug delivery system of
bambuterol hydrochloride was prepared by
adsorption technique using microcrystalline
cellulose:aerosil mixture as the adsorbent. The
formulations were optimized with droplet size of solid
SEDDS100 and 300 nm.
Adsorption to solid carrier(Saggar et
al., 2019)
IloperidoneSyloid XDP and Aerosil 200Solid self microemulsifying drug delivery system
(SMEDDS) and liquisolid compact (LSC) of
Iloperidone were developed (ILO) for improvement of
oral bioavailability. The composition of formulation
Capmul MCM, Labrafac WL 1349 as oils, Lauroglycol
90 and PEG 600 as surfactant and co-surfactant.
Syloid XDP and Aerosil 200 were optimized as carrier
and coating material in the ratio of 15:1 w/w for liquid
solid formulation.
to solid
(Suram et al.,
PiroxicamNeusilin US2 (magnesium aluminometa silicate)Solid self-micro emulsifying drug delivery system was
prepared by adding liquid self-micro emulsifying drug
delivery system with Neusilin US2 and filled in hard
gelatin capsule. The droplet size and PDI value of
optimized batch was found to be 138.8 nm
respectively 0.519 with drug content 98%.
to solid
(Pattewar et
al., 2018)
OstholeEthylcellulose (EC) and Eudragit S100.Solid self-microemulsifying drug delivery system (SSMEDDS) of osthole was developed by spherical
crystallization technique. liquid self-microemulsifying
drug delivery system (L-SMEDDS) of osthole was
formulated with castor oil, Cremophor RH40, and 1,2-
propylene glycol. The optimized osthole S-SMEDDS
had a high yield (83.91 ± 3.31%) and encapsulation
efficiency (78.39 ± 2.25%).
n technique.
(Sun et al.,
FenofibrateSanta Barbara Amorphous15 (SBA-15) mesoporous silica and Aerosil® 200
with soluplus (inhibitor)
Novel supersaturated Solid self-emulsifying drug
delivery system (super-SSEDDS) was developed by
combining SSEDDS with appropriate precipitation
inhibitor to overcome the thermodynamically
instability and precipitation rapidly prior to absorption,
resulting in compromised bioavailability. Particle size
of Solid self-emulsifying drug delivery
system125.23±1.50 nm while supersaturable solid having 132.78±1.27 nm.
ble solid
(Quan et al.,
PaclitaxelAerosil 200Paclitaxel (Ptx) solid-self-emulsifying drug delivery
system (S-SEDDS) was created using the spray
drying approach to increase Ptx's low bioavailability
(BA). According to their solubilizing power, 10% oil
(ethyl oleate), 80% of a surfactant mixture (Tween 80:
Carbitol, 90:10, w/w), and 10% of a cosolvent (PEG
400) were selected. The prepared S-SEDDS had
mean droplet sizes of 16.9 1.53 nm, zeta potentials of
12.5 1.66 mV, and encapsulation efficiencies of 56.2
8.1%, respectively.
Spray drying(Cho et al.,
AtorvastatinLactose (Lactochem® powder)Liquid and solid self-emulsifying drug delivery
systems (SEDDS) for poorly soluble atorvastatin was
developed by spray drying technique. The liquid
formulation was optimized by droplet size and zeta
potential of CF 3 (188.1 ± 1.48 −30.2 ± 1.21) and OF
2 (190.5 ± 1.28−32.0 ± 3.20). Solid formulation have
Particle size 330 nm with entrapment efficiency 52-53
% (EE). Better solubilisation properties were
exhibited by solid formulation OF2 in-compare to
liquid SEDDS formulation.
Spray drying(CzajkowskaKośnik et al.,

Download the full article as PDF here: Hot-Melt Extrusion as Advanced Approach for SEDDS

or read it here

Shahid Jamil, Tariq Waece Sadeq, Abdul Samad, Hot-Melt Extrusion (HME) Is Advanced Approach for Development of Solid Self Emulsifying Drug Delivery System,, International Journal of Membrane Science and Technology · August 2023, DOI: 10.15379/ijmst.v10i2.3187

Watch the recorded webinar Spray Drying – Web Seminar Series here:

Spray Drying - Second web-seminar of the Amorphous Solid Dispersion (ASD) Web-Seminar Series
Spray Drying – Second web-seminar of the Amorphous Solid Dispersion (ASD) Web-Seminar Series
You might also like