Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a Way to Improve the Release Profile

Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an upgraded drug form. The samples of silica materials were obtained by means of modified Stöber synthesis, and their morphological properties were analyzed using Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET) method, elemental analysis (EA), thermogravimetric analysis (TGA), analysis of the specific surface properties, X-ray diffraction study (XRD), scanning electron microscope (SEM), and dynamic light scattering (DLS) methods, which permitted the selection of the drug carrier. The two obtained silica carriers were coated with chloramphenicol and loaded into 1% carbopol gel. The release studies were then performed. The release results were evaluated using mathematical models as well as model-independent analysis. It was found that the modification of the synthesis of the silica by the sol-gel method to form a product coated with chloramphenicol and further grinding of the silica material influenced the release of the active substance, thus allowing the modification of its pharmaceutical availability. The change in the parameters of silica synthesis influenced the structure and morphological properties of the obtained silica carrier. The grinding process determined the way of adsorption of the active substance on its surface. The studies showed that the proper choice of silica carrier has a considerable effect on the release profile of the prepared hydrogel formulations.

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Materials:

Tetraethoxysilane—TEOS 99.99% (Aldrich Chemistry, Darmstadt, Germany); water ammonia solution 25% (Chempur, Piekary Slaskie, Poland); anhydrous ethanol (46.07 g/mol, JT Baker, Phillipsburg, NJ, USA); purified water (obtained with Polwater deionizer CNX-100T 717); sodium hydroxide (Chempur, Piekary Slaskie, Poland); chloramphenicol FPV (PPH Galfarm, Cracow, Poland); and carbopol 934P (BF Goodrich, Cleveland, OH, USA).

Balwierz, R.; Bursy, D.; Biernat, P.; Hudz, N.; Shanaida, M.; Krzemiński, Ł.; Skóra, P.; Biernat, M.; Siodłak, W.O. Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a Way to Improve the Release Profile. Pharmaceuticals 2022, 15, 703. https://doi.org/10.3390/ph15060703