Most recent FDA approval for drugs using Vitamin E TPGS in the formulation
Ubrelvy™ December 2019 and Koselugro™ April 2020 are the most recent FDA approval of drug using Vitamin E TPGS in the formulation.
TPGS properties: Emulsifier – solubilizer of poorly soluble drugs – absorption enhancer – PgP inhibitor – plasticizer for HME – stabilizer of Amorphous Solid Dispersion (ASD) – antioxidant
PMC Isochem offers ISODEL Vitamin E TPGS USP, IV, Food grade.
See also the video on Vitamin E TPGS:
PMC Isochem Vitamin E TPGS is a versatile excipient used in pharmaceutical and nutraceutical applications. It has proven properties to improve bioavailability of poorly soluble drugs, vitamins and micronutrients acting as a solubilizer, absorption and permeability enhancer.
Also, it is a functional ingredient of Self-Emulsifying Drug Delivery System (SEDDS), a stabilizer of amorphous solid dispersion and a plasticizer/binder for innovative technologies in the pharmaceutical industry such as hot melt extrusion .
Vitamin E TPGS is also used as an efficient source of natural Vitamin E, both for therapeutic purposes and nutrition.
Order a sample here