Polyfunctional Siloxane Water-Soluble Nanoparticles for Biomedical Applications

Most of antibacterial and antiviral agents and drugs for the treatment of central nervous system and cancer are water-insoluble, which reduces their bioavailability. The bioavailability of substances can be increased by using a dosage form such as nanosuspension . Multifuctional linear polymers are currently most popular and widely used for biomedical applications, in particular, for the preparation of nanosuspensions. Dendrites are intensely studied as regards the use for increasing the solubility of various drugs and hyperbranched polymers. Nanoparticles based on mesoporous silica can also be used as delivery systems, since silicon dioxide is chemically inert, thermally stable, and biocompatible. However, organic-inorganic hybrid materials seem to be the most attractive delivery agents. Hydrolysis of tetraethoxysilane (TEOS) or trialkoxysilanes containing various organic substituents or co-hydrolysis of these compounds can give siloxane-based nanoparticles with a functionalized surface. Apart from water solubility and the lack of toxicity, an important characteristic of these drug delivery systems is the presence of numerous readily accessible functional groups for the interaction with the drug being delivered. This communication describes the synthesis of a new organosilicon sol-gel monomer as well as solvating properties of water-soluble polyfunctional nanoparticles obtained by its hydrolysis.

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