Glycerin

1| HARD FACTS ABOUT OUR HARD FATS The brand name WITEPSOL® is synonym for hard fats mainly used in  suppositories and ovules. Development and production of WITEPSOL® started back in the 1950s at the former Chemische Werke Witten, now known as IOI Oleo GmbH. Manufacturing takes place in a fully…
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Glycerides are the main components of oils, and fats, used in formulated products in the food and cosmetic industry as well as in the pharmaceutical product industry. However, there is limited literature available on the analysis of the chemical composition of glycerides. The lack of a suitable…
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Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential oils obtained from plant origin only 300 essential oils…
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Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents. It has no odor and no taste. It is used as lubricant, coating agent for the protection of sensitive drugs, in taste masking and as a matrix former in sustained release. Compritol® 888 ATO is an ester of mono-,…
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The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®) as carriers for pediatric applications. The extruded…
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In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc. Owing to the flexibility and biocompatibility, the lipid-based nanocarriers, including…
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Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent. These will be explained and illustrated throughout this Guideline. Download Gattefossé guidelines and get practical tips for successful formulation of sustain release tablets with Compritol® 888 ATO -…
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Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions. In this…
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Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal…
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Implication of Quantitative Selection of Each Excipient in Product Development Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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