Pharma Excipients
Glycerin
Correlation between the solid state of lipid coating and release profile of API from hot melt coated…
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions.
In this…
Read More...
Read More...
Effects of Drugs and Excipients on Hydration Status
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal…
Read More...
Read More...
Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
Read More...
Read More...
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-month storage at 40°. Lactose-containing…
Read More...
Read More...
Personalized orodispersible films by hot melt ram extrusion 3D printing
13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations which can be also implemented in a pharmacy setting. First,…
Read More...
Read More...
Selecting Excipients for Liquid-Filled Hard Capsules
Thixotropic gels, thermosoftened systems, and self-emulsifying systems have expanded the range of potential excipients.
Liquid-filled hard capsules (LFHCs) are typically composed of a shell of gelatin or hydroxypropyl methylcellulose (HPMC) and filled with compatible liquids or…
Read More...
Read More...
Optimization of taste-masking on ibuprofen microspheres with selected structure features
20. June 2018
The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable…
Read More...
Read More...