Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery?

13. August 2021

Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one...

graphical abstract of Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations

Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations

11. August 2021

Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the oral delivery of poorly water-soluble drugs. However,...

See the overview of Parteck® Functional Excipients

10. August 2021

When you design a solid dosage form, there are many factors to consider: the active ingredient, bioavailability enhancement, release kinetics, specific...

Figure 3. Lipid digestion and drug solubilization process in the small intestine. Abbreviation: triglycerides (TG), di-glycerides (DG), monoglycerides (MG), fatty acids (FA), cholesterol (CHL), bile salts (BS), lipoproteins (LP), phospholipids (PL).

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

9. August 2021

Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems...

Formulation and Characterization of Eplerenone Mucoadhesive Buccal Tablets

4. August 2021

Mucoadhesive drug release system is a preferably unidirectional release system where mucosal epithelial exterior is enclosed by the mucus deposit...

P-gp efflux mechanism. (a) “ATP hydrolysis as the power stroke” model and (b) “dimerization of the two ATP-binding sites as the power stroke” model describing the transport cycle of P-gp.

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

26. July 2021

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor...

Figure 5. SeDeM-ODT Diagram for: SRB, PODTG2, PETsp, CELMC, MNT, CCS, LCT, EMCS, and SeDeM for SSG

Pharmacotechnical and Analytical Preformulation Studies for Cannabidiol Orodispersible Tablets

23. July 2021

Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging....

graphical abstract of Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy

Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy

18. July 2021

Poorly absorbable sugar alcohols (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active...

Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced tissue injury

15. July 2021

Curcumin (CUR) shows great potential in the management of alcohol-use disorders. However, the hydrophobicity and poor oral bioavailability result in...

Global desirability as a function of % Smix and % oil.

Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and Evaluation

8. July 2021

Our work is aimed at exploring the composition and the properties of microemulsion (ME), as a drug delivery system, to...

Oral Excipients