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Ethyl Cellulose
Tableting of coated multiparticulates: Influences of punch face configurations
Abstract
The influences of the punch face design on multi-unit pellet system (MUPS) tablets were investigated. Drug-loaded pellets coated with sustained release polymer based on ethylcellulose or acrylic were compacted into MUPS tablets. Punch face designs used include standard concave, deep…
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pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria to the colon remains a challenge. Furthermore, current oral formulations, such as lyophilized bacterial capsules or tablets, are produced using processes that can decrease…
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The impact of applying an additional polymer coating on high drug-loaded amorphous solid dispersions…
Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study was to investigate the potential surface crystallization inhibitory effect of an additional polymer coating…
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The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug…
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Acetaminophen Synthesis and Encapsulation using Safe Mixed-Solvents and Solution Enhanced Dispersion…
Acetaminophen (ACMP) was synthesized in mixed-solvents (H2O-acetone, H2O-dimethyl sulfoxide, H2O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H2O-acetone solvent-pair gave synthesized ACMP yields of 79.2%. Synthesized ACMP samples were encapsulated using…
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Development and Optimization of Microballoons Assisted Floating Tablets of Baclofen
The objective of the present study was to develop microballoons aided gastro-retentive floating tablets of baclofen, a skeletal muscle relaxant with a low elimination half-life of ~ 3.5 h. Baclofen floating tablet was prepared to offer convenience by designing a tablet that would float in the…
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Formulation performance window for manufacturing cellulose-based sustained-release mini-matrices of…
The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for fabricating sustained-release mini-matrices (pellets) of a highly water-soluble drug, tramadol hydrochloride. The current work was designed to identify a formulation window with target functional performances…
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A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can pose the risk of tube clogging. Compared to the…
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Optimized hydration dynamics in mucoadhesive xanthan-based trilayer vaginal films for the controlled…
Karaya gum, pectin and xanthan gum have been tested as candidates for manufacturing mucoadhesive trilayer films containing ethylcellulose and chitosan for the vaginal administration of the antiviral Tenofovir (TFV). The swelling profile correlated with the amount of mobile dipoles determined by …
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Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded…
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was…
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