Browsing Category
HPC – hydroxypropyl cellulose
A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining…
Objective:
This study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection.
Methods:
A 23 factorial experiment was planned to define the best formulation for the development of the base tablet,…
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Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve Prescribed Medication…
Oral drug delivery is currently the gold standard in the pharmaceutical industry, regarded as the safest, most convenient and most economical method of drug delivery with the highest patient compliance . Among oral formulations, tablets and capsules are the most preferred dosage forms, but there are…
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Orodispersible Films: Current Innovations and Emerging Trends
Abstract
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery…
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Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its…
In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investigated as pre-formulation strategies using various…
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Effect of Powdered Cellulose Nanofiber with Different Particle Sizes on the Physical Properties of…
Abstract
Direct compression is a tableting technique that involves a few steps in non-demanding manufacturing conditions. High strength and rapid disintegration of tablet formulations were previously achieved through the addition of cellulose nanofibers (CNFs), which have recently attracted…
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3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the…
Established medicines are often not tailored to the needs of the pediatric population, causing difficulties with administration or dosing. Three-dimensional (3D) printing technology allows novel approaches for compounding of personalized medicine, as is exemplified in this study for the automated…
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Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly soluble drugs and subsequent…
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Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique…
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Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused…
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial…
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