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HPC – hydroxypropyl cellulose
Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine…
Abstract
Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma.
Background:…
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A Novel Semi-Automated Pipeline for Optimizing 3D-Printed Drug Formulations
Abstract
3D printing offers a promising approach to creating personalized medicines. However, costly, expertise-dependent trial-and-error methods hinder efficient drug formulation, posing challenges for tailoring treatments to individual patients. To address this, a novel pipeline is developed for…
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Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Abstract
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are still overlooked in pharmaceutical research and development. These disparities contribute to adverse effects and increased mortality in females, highlighting the critical…
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Development of mucoadhesive films with high polaprezinc content for oral mucositis: A study on…
Abstract
Polaprezinc (PLZ) has drawn attention to its potential to prevent oral mucositis caused by chemotherapy and radiotherapy. PLZ-containing lozenges have been developed in previous reports; however, for patients with mucositis, taking them may be challenging because of pain. Therefore, this…
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Direct powder extrusion (DPE) 3D-printing of mini-tablets for preclinical studies in rodents
Abstract
3D printing (3DP) plays a crucial role in accelerating formulation processes and significantly reduces the time needed to transition from concept to prototype. This technology is particularly valuable as it allows researchers to quickly adjust the structure and composition of dosage forms…
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Expediting 3D printed medication development using vacuum compression moulding
Abstract
Three-dimensional printing (3DP) is a disruptive technology for producing medications tailored to individual patients, with fused-deposition modelling (FDM) being one of the most established technologies for clinical implementation. However, obtaining FDM pharma-ink (drug-loaded filaments…
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The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals
Abstract
Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization is further enhancing this…
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Engineering pH-Dependent Orally Disintegrating Tablets for Modified Indomethacin Release: A…
Abstract
The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
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Towards Enhanced Solubility of Cannabidiol: Preparation and Evaluation of Cannabidiol Solid…
The present study aims to develop and characterize cannabidiol (CBD) solid dispersions using Vacuum Compression Molding (VCM) to enhance the drug solubility and release profile. Solid dispersions of CBD and polymers were processed using VCM at 130 °C for 4 min after a prior physical mixing. Five…
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In-situ forming solvent-induced phase inversion (SIPI) implants for controlled drug delivery: role…
In recent years, there has been a surge of research focused on in situ-forming implants as a method of localized drug delivery. Despite advancements, the predominant challenge in situ-forming solvent-induced phase inversion (SIPI) implants is significant burst release which typically occurs within…
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