Organic Chemicals

Machine vision systems have emerged for quality assessment of solid dosage forms in the pharmaceutical industry. These can offer a versatile tool for continuous manufacturing while supporting the framework of process analytical technology, quality-by-design, and real-time release testing. The aim of…
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Abstract Aim: The research aimed to design the glimepiride self-micro emulsifying drug delivery system (SMEDDS) for increased oral bioavailability in albino mice by assessing hypoglycemic efficacy. Materials and Methods: The optimized liquid SMEDDS (L-SMEDDS) prepared by emulsification of…
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Abstract Swallowing oral solid dosage forms is challenging for those who have medication swallowing difficulties, including patients with dysphagia. One option is to mix the drug (whole or crushed) with a thick vehicle (medication lubricant). Previous in vitro studies consistently suggest that…
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JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the third poster: Introduction Currently in the small-molecule therapeutic arsenal around40%oftheactivepharmaceuticalingredients (APIs) are poorly water-soluble with up to 90 % of the APIs in current development…
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Abstract Hydrophobic drugs exhibit altered bioavailability and pose other challenges at an industrial level due to their poor solubility and dissolution rates. In addition, poor flowability, compressibility, complex dosing schedules, and light-sensitivity problems associated with hydrophobic…
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Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the…
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Abstract Surface powder sticking in pharmaceutical mixing vessels poses a risk to the uniformity and quality of drug formulations. This study explores methods for evaluating the amount of pharmaceutical powder mixtures adhering to the metallic surfaces. Binary powder blends consisting of…
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This poster by Glatt Pharmaceutical Services was presented at the PBP World Meeting 2024: Introduction ProCell® Technology is a continuous spouted bed pelletization process which allows the manufacture of pellets with very high active drug loadings (> 95 %) and narrow particle size…
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Abstract Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the second poster: Introduction Roll compaction/dry granulation (RCDG) is nowadays not only applied for water or heat sensitive active pharmaceutical ingredients, but has become a standard technique in…
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