Organic Chemicals

Abstract The generation of N-nitrosamine compounds (NOCs) in drugs presents a critical regulatory challenge owing to their potential mutagenicity and exceptionally...

Abstract Punch sticking is a well-recognized and extensively studied challenge in pharmaceutical tablet manufacturing. However, the impact of solid-form impurities...

Abstract Press-coated tablets (PCTs) are a modern dosage form designed to circumvent the negative effects of liquid and heat exposure...

Understanding the distribution and integrity of coating layers within enteric-coated pharmaceutical beads is essential for ensuring reliable performance during manufacturing...

Abstract Despite various attempts at solubility enhancement and advances in formulation technologies, improving the bioavailability of poorly water-soluble compounds remains...

Abstract Alfuzosin hydrochloride, an α1-adrenergic antagonist used in the treatment of benign prostatic hyperplasia (BPH), was formulated as orodispersible tablets...

A ready-to-use HPMC film coating improved moisture sealing over a standard HPMC formulation and performed similarly to a PVA-based coating...

Influence of Water on the Structure of MCC Influence of Water on the Structure of MCC describes how moisture reshapes...

Abstract The stability of moisture-sensitive active pharmaceutical ingredients (APIs) in solid dosage forms is a key determinant of product quality...

Abstract We developed a headspace gas chromatography method with flame ionization detection (HSGC-FID) for trace nitrite determination in pharmaceutical excipients....