Pharma Excipients
Povidones
3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and…
Abstract
The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the…
Read More...
Read More...
Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic screening of excipients was conducted to determine the most…
Read More...
Read More...
Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on…
Read More...
Read More...
Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of…
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of…
Read More...
Read More...
Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel…
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility enhancement and controlling the simultaneous release of both…
Read More...
Read More...
Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery…
Quercetin, as a representative flavonoid, is widely present in daily diet and has been developed as a dietary supplement due to its beneficial physiological activities. However, the application of quercetin is limited due to its poor water solubility and extensive metabolism. So far, the nano-drug…
Read More...
Read More...
Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw…
Abstract
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was…
Read More...
Read More...
Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a…
As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that usually consist of a combination of liquid lipids, cosolvents,…
Read More...
Read More...
Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via…
Opioid misuse is a public health crisis in the United States. In response, the FDA has approved drug products with abuse-deterrent features to reduce the risk of prescription opioid abuse. Abuse-deterrent formulations (ADFs) typically employ physical or chemical barriers or incorporate…
Read More...
Read More...
Novel inhalable powder formulation of pirfenidone with sustained release properties to improve…
Abstract
The aim of this study was to develop a new respirable powder (RP) formulation of pirfenidone (PFD) with sustained release properties to ameliorate the pharmacokinetic drawbacks of the previously-developed PFD-RP on rapid elimination from the lung after insufflation. Based on screenings…
Read More...
Read More...