Description

Pemulen™ TR-2 NF polymer is a primary oil-in-water emulsifier which can emulsify up to 50% oil by weight. It is an emulsion former, not an emulsion stabilizer like many of the Carbopol^® polymers. Pemulen™ TR-2 NF polymer can enable formulation of permanent emulsions at very low use levels of the polymer (less than 0.3 wt.%), even at elevated temperatures, without the use of irritating surfactants.

Emulsions based on Pemulen™ polymers deposit an occlusive layer on the skin, delivering the topical medication in the form of low-irritancy lotions and creams with elegant skin feel. Pemulen™ TR-2 NF polymer can also be used for high-clarity topical gels with ionic components.

Pemulen in general: Pemulen^™ polymeric emulsifiers are high molecular weight copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol. These pharmaceutical excipients provide effective emulsification properties to form stable oil-in-water emulsions. Pemulen polymer excipients contain both hydrophilic and hydrophobic portions and serve as excellent gel forming polymers, creating a network around suspended oil droplets and providing exceptional emulsion stability, often without the need for additional surfactants.

These pharmaceutical excipient emulsifiers are ideal for use in topical drug delivery, transdermal drug delivery, and other mucosal applications, such as ophthalmic drug delivery. Pemulen polymers help create low irritancy creams and lotions, providing optimal aesthetics, feel, and drug penetration into the membrane, as well as efficacious, non-irritating emulsion eye drops. Pemulen acrylic acid polymer excipients also provide viscosity building and high yield value to allow for suspension and stabilization of insoluble particulates.

Additional information

Manufacturer	Lubrizol
Quality	USP/NF
Dosage Form	Topical
Function	Emulsifier, emulsion former
Composition	high molecular weight copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol