Abstract Lipid nanoparticles (LNPs) are widely employed for delivering nucleic acids, such as mRNA, in both vaccines and therapeutic applications. These LNPs generally include an ionisable lipid (typically ∼ 50 %) to facilitate nucleic…

Abstract Since the FDA approval of the first nanodrug Doxil® in 1995, twenty subsequent liposome-and lipid nanoparticle (LNP) based drugs (of which 10 are nanodrugs), were approved by the FDA. The application of such drug-products was…

Abstract Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context,…

Abstract Background: Liver fibrosis is a necessary pathological process in many chronic liver diseases. Studies have shown that the progression of chronic liver disease can be slowed by rational intervention in hepatic fibrosis. Berberine…

This poster was presented at the DDF Summit Conference 2024 by Valentyn MOHYLYUK, Zoltán Márk HORVÁTH, Kirils KUKULS, Liga LAUBERTE, Artūrs PAULAUSKS from Rīga Stradiņš University: Introduction Replacing batch wet granulation with…

Uncontrolled hemorrhage remains a critical threat in trauma and surgery. This study developed a novel hemostatic composite by encapsulating Peganum harmala L. seed extract (PH) with known hemostatic properties into lipid nanocapsules…

Drug delivery to the inner ear presents a unique challenge due to the complex inner ear anatomy and its tight physiological barriers. This study investigates the degradation behavior of intracochlear drug delivery implants (IDDI) composed…

Twin-screw melt granulation (TSMG) is one of the promising green technological approaches for the manufacturing of solid dosage forms of pharmaceuticals and nutraceuticals. PEG 8000 is one of the most popular TSMG binders. The effect of…

Introduction High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining…

A nanocapsule shell of poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) mixed with anionic Eudragit S100 (90/10% w/w) was previously used to entrap and define the self-assembly of indigo carmine (IC) within the hydrophilic…