Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Study of the feeding performance of mesoporous silica in a loss-in-weight feeder
Accurate and reliable continuous feeding is essential for the continuous manufacturing of solid-dose pharmaceuticals to ensure the reproducible composition of the final product. Consistent feeding of cohesive powders is challenging and requires an understanding of the interplay between material…
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Study of diminutive granules as feed powders for manufacturability of high drug load minitablets
The maximal amount of drug contained in a minitablet is limited. To reduce the total number of minitablets in a single dose, high drug load minitablets can be prepared from high drug load feed powders by various pharmaceutical processing techniques. Few researchers have however examined the…
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Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
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Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for…
Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the…
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SIPERNAT®, ZEOFREE® and AEROSIL® for Spray Drying Operations – Technical information by Evonik
Introduction
Spray drying is a common process to isolate solid products from emulsions, dispersions or solutions.
A wide range of products are produced by spray drying:
Food products
(e.g., tomato powder, soup mixes, flavors,
non-dairy creamer, egg powder)
Milk and Dairy products…
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Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application
Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell…
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Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The…
Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadings (DL) was used in multi-component blends to…
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Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New…
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Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and Neusilin® US2) through a screening plan. The enhancement of…
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Cationic Solid SMEDDS of Efavirenz for Improved Oral Delivery: Development by Central Composite…
Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design were employed in design. Globule size, TEM, DSC, and SEM studies…
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