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Solid Dispersion
Sustained release polymer and surfactant based solid dispersion of andrographolide exhibited…
Andrographolide (AD) is a potent natural product with a wide range of pharmacological activities. However, it has low oral bioavailability due to poor solubility and dissolution rate. Solid dispersion (SD) is a promising technique to improve the solubility and dissolution rate of such molecules. In…
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Material-Sparing Feasibility Screening for Hot Melt Extrusion
Abstract
Hot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at determining the thermodynamic solubility and…
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Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using…
Abstract
Objective: Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.
Significance: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve…
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Fused Deposition Modelling 3D printing and solubility improvement of BCS II and IV active…
Abstract
In the field of pharmaceutical research and development, Fused Deposition Modelling (FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of thermoplastic polymers, combined with the melting process of the raw materials, offers the possibility of…
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Comprehensive Evaluation of Polymer Types and Ratios in Spray-Dried Dispersions: Compaction,…
Abstract
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet form. However, the influence of common polymers and drug loading on the manufacturability of ASD…
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Polymer selection for amorphous solid dispersion of a new drug candidate by investigation of drug…
The antitumor drug candidate X-05 is being developed as an innovative anti-lung cancer drug candidate due to its excellent antitumour activity. A Caco-2 cell permeability study and solubility study confirmed that X-05 belonged to BCS class II or IV compounds. Therefore, the main challenge is to…
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Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its…
In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investigated as pre-formulation strategies using various…
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Enhancing the solubility and dissolution rate of piperine via preparation of piperine–hydroxypropyl…
Abstract
Context:
Piperine is the main secondary metabolite isolated from the family Piperaceae. This biologically active ingredient has many pharmacological effects, though its low water solubility limits its absorption in gastrointestinal fluid.
Aims:
To improve piperine’s solubility and…
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Supercritical fluid technology as a strategy for nifedipine solid dispersions formulation: in vitro…
Abstract
Supercritical fluid technology (SFT) is an insufficiently investigated approach for the production of solid dispersions, it is environmentally acceptable and has a high potential for application in the pharmaceutical industry. The aim of this work was to formulate and characterize…
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Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly…
Abstract
Objectives
The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide.
Methods
The solvent evaporation method made SDs of…
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