Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of Lopinavir by Spectroscopic-chemom

graphical abstract of Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of Lopinavir by Spectroscopic-chemometric Methods

Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of Lopinavir by Spectroscopic-chemometric Methods

6. May 2021

This study aimed to improve the dissolution of the poorly soluble drug lopinavir (LPV) by preparing amorphous solid dispersions (ASDs)...

graphical abstract of Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive drugs: formulation, in vitro evaluation and molecular metadynamics simulations

Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive drugs: formulation, in vitro evaluation and molecular metadynamics simulations

30. April 2021

The purpose of this study was to associate the poorly water-soluble antihypertensive drugs candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ) as...

Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability

30. April 2021

Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of...

Exploring novel carrier for improving bioavailability of Itraconazole; Solid dispersion through Hot Melt extrusion

27. April 2021

Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown...

Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs

19. April 2021

Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents...

Nateglinide solid dispersion optimized formulation

Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions

11. April 2021

The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release...

graphical abstract of Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions In Vitro and In Situ Evaluation

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

21. March 2021

The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by...

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

19. March 2021

Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug...

Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid dispersions

19. March 2021

Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and...

Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions

13. February 2021

Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble...

Solid Dispersion

Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of Lopinavir by Spectroscopic-chemometric Methods

Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive drugs: formulation, in vitro evaluation and molecular metadynamics simulations

Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability

Exploring novel carrier for improving bioavailability of Itraconazole; Solid dispersion through Hot Melt extrusion

Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs

Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid dispersions

Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions

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