Development of long-acting imidafenacin transdermal patches with high drug loading based on solid dispersion technology

31. May 2025

Abstract Imidafenacin tablets are the first-line drug for the treatment of overactive bladder (OAB). However, the tablets need to be...

Tailoring the release of highly loaded amorphous solid dispersions via additive manufacturing

9. May 2025

Abstract In the last decades, tremendous improvements have been made in enhancing the bioavailability of poorly soluble active pharmaceutical ingredients...

A powerful carrier adapted for HME process to formulate stable ASD’s while avoiding downstream process – ECP 2025 Poster

10. April 2025

This poster was presented at the ECP 2025 in Porto Introduction Hot melt extrusion (HME) is generally applied for the...

A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs

29. March 2025

Abstract The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market...

Compaction Characterisation of Piroxicam Amorphous Solid Dispersions Formulations

27. March 2025

See another MEDELPHARM bulletin: Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs...

Formulation Development and Compaction of Itraconazole Amorphous Solid Dispersions Tablet Using Quality by Design Principles

20. March 2025

Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4 ng/ mL in water) requires formulation enhancement to achieve...

Increased Dissolution Rate And Decreased Processing Temperature For Immediate Release FDM 3d Printed Tablet Of Weakly Acidic Drugs By Acid-Base Supersolubilization

20. March 2025

In recent years, there has been much interest in three-dimensional (3D) printing for the development of personalized and on-demand medications...

Development and characterisation of polymeric solid dispersed systems of hesperidin, obtained by centrifugal fibre formation

18. March 2025

Abstract The flavonoid hesperidin is a crucial, biologically active substance of great interest because of its polypharmacological properties and high...

Development of tablet formulations containing genistein solid dispersion optimized using Box-Behnken design for enhanced solubility

3. March 2025

Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This...

Developing Soluplus®-Based Microparticle Amorphous Solid Dispersions with High Drug Loading for Enhanced Celecoxib Dissolution via Electrospraying

23. February 2025

Abstract Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble...

Solid Dispersion