Solid Dispersion

Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug...

Abstract The purpose of this study was to develop and evaluate a sublingual tablet of lercanidipine hydrochloride for the direct...

Abstract α-Lipoic acid (LA), a naturally occurring antioxidant and anti-inflammatory agent, has limited aqueous solubility and bioavailability which hinders its...

Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug...

Abstract Imidafenacin tablets are the first-line drug for the treatment of overactive bladder (OAB). However, the tablets need to be...

Abstract In the last decades, tremendous improvements have been made in enhancing the bioavailability of poorly soluble active pharmaceutical ingredients...

This poster was presented at the ECP 2025 in Porto Introduction Hot melt extrusion (HME) is generally applied for the...

Abstract The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% of new drugs face market...

See another MEDELPHARM bulletin:  Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs...

Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4 ng/ mL in water) requires formulation enhancement to achieve...