Solids

As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that usually consist of a combination of liquid lipids, cosolvents,…
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Abstract Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming…
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The Application of Fillers and Binders in Solid Dosage Formulation Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties that offer greater flowability and compressibility which…
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Abstract Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing…
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This case study aimed to evaluate the feasibility of forming equimolar co-amorphous drug-phospholipid systems by different preparation methods. Indomethacin (IND) was chosen as a model drug and combined with three phospholipids of natural origin (soybean phosphatidylcholine (SPC), hydrogenated…
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The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot…
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Abstract Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit…
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Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
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INTRODUCTION Mannitol is the first intention excipient for oral solid forms, designed for APIs having stability problems. Mannitol is not hygroscopic and presents a high chemical stability; therefore, it is considered compatible with almost all drugs. To combine its high stability properties…
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Abstract Drug loading into mesoporous carriers may help to improve the dissolution of poorly aqueous-soluble drugs. However, both preparation method and carrier properties influence loading efficiency and drug release. Accordingly, this study aimed to compare two preparation methods: formulation…
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