Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently
on the market or under development. Several formulation strategies including salt formation,
particle size reduction, and solid dispersion approaches have been employed with varied success.
In this review, we focus primarily on the emerging trends in the generation of amorphous and
micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and
in turn the bioavailability of poorly water-soluble drugs.
Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions. Do you want to read the full article?