Spray drying

Abstract The dynamics of cohesive particles and their tendency to adhere to surfaces present significant challenges in various industrial processes. A profound understanding of adhesive and cohesive forces is crucial for the optimized design of continuous manufacturing systems, aiming to…
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Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue as public health concerns. Inhaled drug therapy for TB has substantial benefits in combating the causal agent of TB (Mycobacterium tuberculosis). Pretomanid is a promising candidate in an optional…
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The present study aimed to develop redispersible spray-dried powders containing curcumin-loaded Eudragit® L100 nanocapsules and evaluate their physicochemical properties and antioxidant potential. The spray drying process showed a yield of over 85%, low residual moisture content (<2%), and all…
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Introduction Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions. Liquid vaccines face the risk of chemical degradation and physical instability -> Solid formulations can…
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Abstract Roller compaction is a widely used continuous dry granulation process in the food and pharmaceutical industries. The flow and distribution of the powder across the rollers in the compaction area plays a crucial role in determining the quality of the final product. Non-uniform powder flow…
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Abstract Background: Fenofibrate (FF) is a BCS class II compound whose poor solubility poses challenges in drug delivery and bioavailability. Solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged as a promising solution to address these issues. These systems are aimed at…
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Purpose Continuous manufacturing (CM) gains more and more interest in the pharmaceutical industry, which is guided by the FDA in Pharma 4.0. With CM gaining ever so importance, understanding of physical properties of powders to predict behavior in different process units is crucial. Raw…
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Abstract Biopharmaceuticals are labile biomolecules that must be safeguarded to ensure the safety, quality, and efficacy of the product. Batch freeze-drying is an established means of manufacturing solid biopharmaceuticals but alternative technologies such as spray-drying may be more suitable for…
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This study employed a Quality by Design (QbD) approach to spray dry amorphous clotrimazole nanosuspension (CLT-NS) consisting of Soluplus® and microcrystalline cellulose. Using the Box-Behnken Design, a systematic evaluation was conducted to analyze the impact of in let temperature, % aspiration,…
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Abstract Drug delivery is essential to provide correct treatments in many ways. The critical points in any drug delivery method are patient compliance, maximum efficacy in therapy, minimum toxicity, and enabling new medical treatments. Pulmonary drug delivery is one way of delivering therapeutics…
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