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Spray drying
Optimizing API Load and Minimizing Tablet Weight Leveraging an Innovative DC Mannitol
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Tablets with stability issues often use mannitol, a stable, water-soluble excipient compatible with most drugs. Direct compression is a…
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Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations
Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain applications of biopharmaceutical products can be…
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Utilization and Evaluation of Rice Bran and Rice Bran Wax as a Tablet Lubricant
Abstract
The rice bran and rice bran wax of the KJ CMU107 rice strain were investigated as potential tablet lubricants in a directly compressed tablet formulation. Stabilized full-fatted rice bran (sFFRB), stabilized defatted rice bran (sDFRB), and rice bran wax (RBW) extracted and purified from…
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The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets…
Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the…
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Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride
Abstract
Chitosan, being a biocompatible and mucoadhesive polysaccharide, is one of the most preferred hydrogel-forming materials for drug delivery. The objectives of the present study are to obtain spray-dried microparticles based on low-molecular-weight chitosan and study their potential…
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Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic screening of excipients was conducted to determine the most…
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Influence of Nozzle Geometry and Scale-Up on Oil Droplet Breakup in the Atomization Step during…
Spray drying of oil-in-water emulsions is a widespread encapsulation technique. The oil droplet size (ODS) significantly impacts encapsulation efficiency and other powder properties. The ODS is commonly set to a specific value during homogenization, assuming that it remains unchanged throughout the…
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Enhancement of inhaled micronized powder flow properties for accurate capsules filling
Introduction
Dry powder inhalers (DPI) are gaining popularity in the field of pulmonary treatments due to their numerous advantages. Compared to pressurized metered-dose inhalers (pMDI), soft-mist inhalers (SMI), and nebulizers, which utilize liquid formulations, DPIs employ solid-state…
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Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
The Application of Fillers and Binders in Solid Dosage Formulation
Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties that offer greater flowability and compressibility which…
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Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and…
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable from an economic and ecological perspective but also limited to thermostable active pharmaceutical ingredients (APIs). A potential technology shift from spray-drying to hot-melt extrusion at later stages of drug…
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