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Spray drying
The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, including a solvent-free process, continuous…
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Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products…
Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major…
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Transform Your Brick-Dust API into an Effective oral Drug Candidate with Apinovex Polymers
Lubrizol Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
1. Unlock the Potential Of…
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Engineering the right formulation for enhanced drug delivery
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules and biologics and offer several advantages for inhaled therapy. Early DPI products were intended to treat asthma and lung chronic inflammatory disease by administering low-dose, high-potency drugs blended with …
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Development of spray-dried N-acetylcysteine dry powder for inhalation
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its possible role in reducing the affinity of the spike protein receptor binding domain to angiotensin-converting…
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Apinovex Polymers Enable Solubility With Ease
Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
Solubility-enhancing polymers for oral…
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Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and…
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Optimized L-SNEDDS and Spray-Dried S-SNEDDS Using a Linked QbD-DM3 Rational Design for Model…
A QbD-DM3 strategy was used to design ketoprofen (KTF) optimized liquid (L-SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Principal component analysis was used to identify the optimized L-SNEDDS containing Capmul® MCM NF, 10% w/w; Kolliphor® ELP, 60% w/w; and propylene…
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New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid…
Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on an amorphous API dispersed in a polymer, and their stability is driven by the presence of strong intermolecular…
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A functional study of tubing material for the spray drying of mRNA-lipoplexes
Kiel University, Germany, and Meggle GmbH & Co. KG present "A functional study of tubing material for the spray drying of mRNA-lipoplexes":
INTRODUCTION
The overall aim of this project is the development of an inhalable dry powder platform for mRNA vaccines.
As many viral infections…
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