Evaluation of solid carvedilol-loaded SMEDDS produced by the spray drying method and a study of related substances

27. June 2021

In this study, various formulations of solidified carvedilol-loaded SMEDDS with high SMEDDS loading (up to 67% w/w) were produced with...

graphical abstract of Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes

Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes

26. June 2021

Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL...

Understanding the Impact of Protein–Excipient Interactions on Physical Stability of Spray-Dried Protein Solids

16. June 2021

Mannitol, leucine, and trehalose have been widely used in spray-dried formulations, especially for inhalation formulations. The individual contribution of these...

graphical abstract of Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in amorphous polymer matrix prepared by nano spray drying

Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in amorphous polymer matrix prepared by nano spray drying

15. June 2021

In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology....

Mesoporous silica: a solution for amorphous stabilization of poor glass formers

28. May 2021

Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently,...

A) Quantification of siGFP after spray drying of polyplexes (N/P 5) at various T‐In. B) Agarose gel of redispersed polyplexes after spray drying with indicated T‐In in °C. siGFP was released from polyplexes upon incubation with heparin. Lane 1: internal standard (iS), Lane 2: powder spray dried at 65 °C T‐In, Lane 3: powder spray dried at 145 °C T‐In, Lane 5: low range DNA base pair ladder. C) Quantification of siGFP after pumping polyplexes through standard silicon tubing and Pumpsil tubing (n = 3)

Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano‐in‐Microparticles

12. May 2021

To develop stable and inhalable dry powder formulations with long shelf life, polyplexes consisting of siRNA and a polyethylenimine (PEI)‐based...

Topical cellulose nanocrystals-stabilized nanoemulgel loaded with ciprofloxacin HCI

Topical cellulose nanocrystals-stabilized nanoemulgel loaded with ciprofloxacin HCl with enhanced antibacterial activity and tissue regenerative properties

6. May 2021

Spray-dried cellulose nanocrystals (CNC) were investigated as a potential stabilizer for the preparation of nanoemulsion gels (nanoemulgels) loaded with ciprofloxacin...

Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations for Treating Neonatal Respiratory Distress Syndrome

21. April 2021

This study aimed to develop and characterize a spray-dried powder aerosol formulation of a commercially available surfactant formulation, Survanta® intratracheal...

Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

21. April 2021

Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting...

Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications

9. April 2021

Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence...

Spray drying