Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression

2. July 2021

In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in...

Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

2. June 2021

Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a...

Characterization of a Novel Drying Technology for Continuous Processing of Cohesive Materials: An Ibuprofen Case Study

15. March 2021

This work addresses the influence of several process parameters on the performance of a novel drying device (patent NL2020740B1). In...

Schematic representation of the gravitation-based high-speed compaction device

Evaluating mechanical properties and tabletability of pharmaceutical powders with a novel gravitation-based high-velocity compaction method

15. March 2021

Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing...

Unit operations employed in the production of tablets via granulation or spray:co-spray drying

Spray Drying for Direct Compression of Pharmaceuticals

8. February 2021

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical...

graphical abstract of A novel approach to determine the granule density of milled ribbons using multi-stage air classification combined with dynamic image analysis

A novel approach to determine the granule density of milled ribbons using multi-stage air classification combined with dynamic image analysis

16. December 2020

Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further...

multi-stage air classification roller compacted granules

A novel approach to determine the granule density of milled ribbons using multi-stage air classification combined with dynamic image analysis

15. December 2020

Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further...

Towards better understanding of the influence of process parameters in roll compaction/ dry granulation on throughput, ribbon microhardness and granule failure load

16. November 2020

A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If...

Effect of intra- and extragranular addition of highly porous tribasic calcium phosphate on properties of immediate release acyclovir formulation – Comparison with commercial tablets using compendial and biorelevant dissolution methods

11. November 2020

Immediate release, compositionally proportional formulations of acyclovir comprising porous tribasic calcium phosphate were developed and compared with commercial tablets. Comparison of the dissolution behavior...

Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines

8. November 2020

Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical...

Budenheim