DFE Pharma

Abstract This study explores the potential of spectroscopic analysis combined with Partial Least Squares Regression (PLS) and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) for the simultaneous quantification of antibiotics in multicomponent drug formulations, specifically…
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Abstract We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict and control the solid fraction, as it has a significant impact on the product quality. The solid fraction can be theoretically predicted by a first-principles model…
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Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This study aimed to enhance genistein’s solubility by developing solid dispersion (SD) and formulating them into tablets. The SDs were prepared using…
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Abstract Solid forms transformations and new crystal structures of an active pharmaceutical ingredient (API) can occur due to various manufacturing process conditions, especially if the drug substance is formulated as a hydrate. The conversion between hydrate and anhydrate forms caused by changes…
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Abstract Additive manufacturing has been a breakthrough therapy for the pharmaceutical industry raising opportunities for long-quested properties, such as controlled drug-delivery. The aim of this study was to explore the geometrical capabilities of selective laser sintering (SLS) by creating…
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Abstract Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition locations on deposition efficiency, they have not focused…
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Abstract Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Abstract This study investigated a capsule’s powder evacuation behavior when rotating about its minor axis in a cross flow and considering the effects of rotation speed and flow rate on powder emission. The experimental platform, an optically accessible capsule chamber, was designed to uncover the…
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Abstract Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts…
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Abstract The present study is aimed at formulating serratiopeptidase enteric coated tablets by utilizing the direct compression method and aqueous solvent-based coating. Seven formulations of serratiopeptidase were developed by using excipients such as Magnesium stearate, Talcum, Primojel, and…
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