DFE Pharma

Abstract The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and…
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Abstract Since the FDA approval of the first nanodrug Doxil® in 1995, twenty subsequent liposome-and lipid nanoparticle (LNP) based drugs (of which 10 are nanodrugs), were approved by the FDA. The application of such drug-products was considerably boosted by the mRNA-LNP based vaccines used to stop…
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This poster was presented at the ECP 2025 in Porto A proof of concept with wet extrusion Introduction Veterinary soft chews are gaining interest among oral dosage forms for companion animals as they provide good acceptance for the pet and are easy to administrate by the pet owner,…
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The effect of binder types on the granule properties and tablet quality for high shear wet granulation and tableting (HSWG-T) was studied. Furthermore, attribute correlation was established by multivariate models based on a systematical study of the binder’s properties, wetting mass’s physical…
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The mixing of ductile lubricant particles is known to have several negative effects on tablet properties, such as decreased hardness and delayed disintegration. This study investigated the usefulness of a mixing system using an intensive mixer with a rotating mixing vessel (EIRICH Intensive Mixer)…
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Purpose Understanding batch-to-batch variation of excipients and correlating this to process performance is a key concept of Quality-by-Design for pharmaceutical product development. In this study, the effect of batch-to-batch variation in material properties of milled lactose monohydrate on…
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The pharmaceutical industry has been shifting towards continuous manufacturing, specifically for tablet production. Compared to batch processing, continuous tableting exhibits higher process efficiency, better process control, reduced footprint, and consistent product quality. Understanding mass…
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Abstract Formulation development of protein biopharmaceuticals has become increasingly challenging due to new modalities and higher desired drug substance concentrations. The constraint in drug substance supply and the need for a holistic set of analytical methods means that only a small selection…
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Abstract This study explores the potential of spectroscopic analysis combined with Partial Least Squares Regression (PLS) and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) for the simultaneous quantification of antibiotics in multicomponent drug formulations, specifically…
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Abstract We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict and control the solid fraction, as it has a significant impact on the product quality. The solid fraction can be theoretically predicted by a first-principles model…
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