DFE Pharma

Abstract Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Abstract This study investigated a capsule’s powder evacuation behavior when rotating about its minor axis in a cross flow and considering the effects of rotation speed and flow rate on powder emission. The experimental platform, an optically accessible capsule chamber, was designed to uncover the…
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Abstract Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts…
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Abstract The present study is aimed at formulating serratiopeptidase enteric coated tablets by utilizing the direct compression method and aqueous solvent-based coating. Seven formulations of serratiopeptidase were developed by using excipients such as Magnesium stearate, Talcum, Primojel, and…
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Abstract Previously, a nasal powder formulation of the influenza vaccine was proposed to ensure its stability over fifteen months at room temperature and to have sufficient moisture-resistant characteristics to enable handling without special humidity control. In this study, a carrier-based…
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Abstract Magnesium stearate (MgSt) is a common tablet lubricant. As variations in MgSt properties are known to influence tablet attributes, the impact of MgSt fatty acid composition, particularly the significance of the stearate and palmitate contents, and its effects on tablet properties…
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Abstract Roller compaction is a key unit operation in a dry granulation line for pharmaceutical tablet manufacturing. During product development, one would like to find the roller compactor (RC) settings that are required to achieve a desired ribbon solid fraction. These settings can be…
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Abstract Pharmaceutical peptides are susceptible to aggregation in solution, making stabilization by addition of suitable excipients essential. To investigate this stabilization, lengthy and cost-intensive experiments are often necessary. In this work, a differential scanning calorimetry (DSC)…
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Abstract The pharmaceutical industry is continuously looking for strategies and solutions that can improve quality and efficiency of manufacturing processes. As a result, there has been a significant shift towards continuous manufacturing (CM). Traditionally, tablets have been produced by batch…
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Abstract Ensuring children adhere to their prescribed medication can be challenging, particularly when a large number of medicines on the market consist of unpalatable drugs and difficult to swallow dosage forms. Sugar-based oromucosal films are easy to administer dosage forms across all age…
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