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Evonik
Development of a New Bioequivalent Omeprazole Product
Abstract
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that its population has access to affordable…
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Novel inhalable powder formulation of pirfenidone with sustained release properties to improve…
Abstract
The aim of this study was to develop a new respirable powder (RP) formulation of pirfenidone (PFD) with sustained release properties to ameliorate the pharmacokinetic drawbacks of the previously-developed PFD-RP on rapid elimination from the lung after insufflation. Based on screenings…
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Lamellar double hydroxides as pharmaceutical excipients: a compatibility study
Lamellar double hydroxides (LDH) are a class of inorganic materials widely used as pharmaceutical ingredients. However, their use as excipients and mainly as drug carriers lacks specific research in pharmaceutical technology, as there are no publications capable of defining the behavior of these…
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Development of a Eudragit-based hydrogel for the controlled release of hydrophobic and hydrophilic…
Wounds are a daily occurrence that requires wound dressings to prevent infections and promote healing. Various wound dressing types are used in clinics to prevent infections and promote healing, and dressings vary with the wound's severity and complexity. Hydrogel-based wound dressing offers several…
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Impact of dry coating lactose as a brittle excipient on multi-component blend processability
Abstract
Previous work demonstrated the benefits of dry coating fine-grade microcrystalline cellulose (MCC) for enabling direct compression (DC), a favored tablet manufacturing method, due to enhanced flowability while retaining good compactability of placebo and binary blends of cohesive APIs.…
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Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of…
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound with low solubility and high permeability. Several strategies have been explored to overcome the low bioavailability of RES, making the formation of solid dispersions (SDs) one of the most promising. This study…
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Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis…
Δ9-Tetrahydrocannabinol and cannabidiol, which are present in cannabis extract, exhibit low bioavailability when administered orally due to significant first-pass metabolism. The use of a self-emulsifying drug delivery system (SEDDS) can enhance their dissolution and bioavailability. However, liquid…
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In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
Abstract
Capsaicin (CAP) has been implicated as a gastroprotective agent in the treatment of peptic ulcers. However, its oral administration is hampered by its poor aqueous solubility and caustic effect at high administered doses. To address these limitations, we describe the development of gastric…
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PhytoSquene® – Your plant-derived squalene for parenteral applications
PRESERVING BIODIVERSITY AND ENSURING SAFETY WITH NON-ANIMAL-DERIVED SQUALENE
PhytoSquene® is our non-animal-derived squalene that can be used in vaccines and other pharmaceutical applications. This alternative to animal-derived squalene has many benefits. PhytoSquene® reduces the need to…
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HME as Advanced Approach for Development of Solid Self Emulsifying Drug Delivery System
The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot…
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