Application of Dominance-Based Rough Set Approach for Optimization of Pellets Tableting Process

2. November 2020

Multiple-unit pellet systems (MUPS) oer many advantages over conventional solid dosage forms both for the manufacturers and patients. Coated pellets...

MeltPrep® Vacuum Compression Molding (VCM) process

Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations

28. October 2020

Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it...

Co-administration of mini-tablets orlistat and xanthan gum

Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing orlistat and mini-tablets containing xanthan gum: In vitro and in vivo evaluation

28. October 2020

The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with...

Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

21. October 2020

Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions...

Resulting nanoparticle sizes after spray drying of PLGA:PVA double emulsions

Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders

11. October 2020

To develop a scalable and efficient process suitable for the continuous manufacturing of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing ovalbumin as...

Eudragit E 100

1. October 2020

Commercial form: EUDRAGIT® E 100 Solid substance EUDRAGIT® E 100 is described in the monographs quoted above. EUDRAGIT® E PO...

SEM microphotographs of the particles of neat and extruded experimental polymeric powders

Impact of Hot-Melt-Extrusion on Solid-State Properties of Pharmaceutical Polymers and Classification Using Hierarchical Cluster Analysis

29. September 2020

The impact of hot-melt extrusion (HME) on the solid-state properties of four methacrylic (Eudragit® L100-55, Eudragit® EPO, Eudragit® RSPO, Eudragit®...

Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization

28. September 2020

The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to...

Particle size distribution of coated microparticles (Cellets® 100) using Glatt MultiLab®

Scaling up fluidised bed coating of sustained release microparticles at high spray rate using the MicroCoat™ technology

22. September 2020

Scaling up fluidised bed coating of microparticles with particle size smaller than 150 µm is a challenge because of the...

QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC‑Fluorescence detection method

16. September 2020

This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic...

Evonik