Hayashibara

Abstract Carbohydrates play a pivotal role in reshaping micellar organization. This study explores how glucose (a monosaccharide), trehalose (a disaccharide),...

Abstract Hypothesis During spray freeze drying (SFD), vitrification, recrystallization, and polymorphic transitions govern particle morphology and mechanical integrity. We hypothesize...

Abstract Background/Objectives: Reproducible evaluation of aerosol dispersibility remains a key challenge in the development of dry powder inhalers (DPIs), where small...

Join our inspiring expert talk on Trehalose Enhances Removal:  Description: In this study, adding trehalose during CHO cell harvest resulted...

Abstract Introduction: Formulation research benefits from high-throughput excipient screening methods, considering the ever-growing excipient space. We investigate the use of 384-well...

Abstract Biopharmaceutical medicines represent one of the most dynamic sectors of the pharmaceutical industry, with therapeutic proteins forming the largest...

Abstract Surface adsorption of proteins in bulk drug product formulations and loss of protein structural integrity during manufacturing processes can...

Abstract The transdermal delivery of large molecules such as proteins and vaccines faces enormous challenges and at the same time...

Abstract Lyophilization enhances mRNA vaccine stability, but conventional approaches using external trehalose for lipid nanoparticle (LNP) colloidal stability neglect mRNA...

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by...